Examples of 'elongase' in a sentence
Meaning of "elongase"
elongase (noun) - An enzyme that catalyzes the elongation of a molecule, typically used in biochemistry and molecular biology
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- Any enzyme that catalyzes the elongation of an aliphatic chain, but especially one that elongates a fatty acid
How to use "elongase" in a sentence
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elongase
All clones have apparent elongase activity.
With the elongase of the invention it is also possible to synthesize longer PUFAs.
There have been a large number of attempts in the past to obtain elongase genes.
The elongase genes may be present in one or more copies in the gene construct.
In these biosyntheses use is made of enzymes of the types desaturase and elongase.
The sequence encodes a functionally active elongase which utilizes a polyunsaturated fatty acid as a substrate.
Such oils can only be made by isolation and expression of the elongase gene.
This elongase gene catalyzes some of the elongation steps in the PUFA pathway.
Two genes appeared to be of interest in the present search for the elongase gene.
An elongase may then be used to convert the GLA to DGLA.
One clone contained a complete ASE gene showing weak homology to known elongase genes.
In addition, elongase enzymes also extend acyl chain length in 2 carbon increments.
A method of generating a polypeptide with desaturase or elongase activity, comprising the steps,.
This elongase gene catalyzes the addition of two more carbons to the pre-existing PUFA.
RACE techniques can readily be utilized to isolate the full-length clone encoding the elongase.
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A gene encoding such an elongase has been isolated from an invertebrate, C.
As noted above, DGLA is produced from GLA by an elongase.
This molecule is also the first A5 elongase isolated from an algael source.
Elegans, therefore, may contain a PUFA elongase.
Taq polymerase and Elongase were purchased from Promega and Invitrogen, respectively.
This indicated that the Elo1 gene encodes a specific or selective A5 elongase in yeast cells.
The role of the elongase enzyme ( elo ) should be noted.
The thickened arrow indicates the A5 elongase step.
Occasionally, a delta-6 elongase may elongate fatty acids other than the intended fatty acid.
As described herein, at least one of the enzymes may be a A9 elongase.
In the context of the present invention a A5 elongase catalyzes the conversion of EPA to DPA.
According to the invention, at least one of the enzymes is a A5/A6 bifunctional elongase.
In the context of the present invention a A6 elongase catalyzes the conversion of SDA to ETA.
Figure 44 represents the deduced amino acid sequence of the human elongase HSELO1.
Multizymes comprising delta-9 elongase and delta-8 desaturase and their use in making polyunsaturated fatty acids.
In a seventh embodiment, the invention concerns an isolated polynucleotide encoding a C20 elongase comprising,.
Synthetic delta-9 elongase derived from Eutreptiella sp.
Figure 49 represents the complete nucleotide sequence of the putative human elongase gene HS3.
A6 desaturase and A6 elongase activities were not detected in these species.
This would point towards a common function in the fatty acid metabolism, e . g., a PUFA elongase.
Preferably, the A9 elongase can be purified from algae or fungi.
Figure 50 illustrates the deduced amino acid sequence of the putative human elongase enzyme HS3.
In another embodiment, the A5 elongase can be purified from algae.
In one embodiment, at least one of the enzymes is a A5 elongase.
An isolated polynucleotide encoding a C20 elongase is disclosed herein comprising,.
Figure 6 illustrates the complete nucleotide sequence of Mortierella alpina elongase ( MAELO ).
They also showed that the protein did not have A5 elongase activity on a C20 substrate in yeast.
Preferably, the introduced polynucleotide ( s ) encode a AS/A6 bifunctional desaturase and a AS/A6 bifunctional elongase.
At least one of the enzymes is a A5 elongase also having A6 elongase activity.
The instant invention concerns an isolated polynucleotide encoding a C20 elongase comprising,.
In another aspect, the elongase is a C20 elongase, and the destaurase is a delta-4 desaturase.
Figure 12 illustrates the amino acid sequence encoded by the elongase gene MEL04 from a mouse.
Thus, in an embodiment, the A9 elongase also has A6 elongase activity.
Figure 47 represents the deduced amino acid of C. elegans elongase CEELO.
No sequence homologous to the A5 elongase gene promoter sequence ( SEQ ID NO, 19 ) was found.
