Examples of 'endostatin' in a sentence
Meaning of "endostatin"
'Endostatin' is a noun that refers to a naturally occurring protein in the human body. It plays a role in inhibiting the growth of blood vessels, and it has been studied for its potential use in cancer treatment
Show more definitions
- A protein which inhibits the formation of the blood vessels that supply tumours.
How to use "endostatin" in a sentence
Basic
Advanced
endostatin
Endostatin is currently being studied as part of cancer research.
The action mechanism of endostatin remains unknown.
This inhibitory protein has been named endostatin.
Several forms of endostatin are observed by western blots.
Currently preferred fusión proteins are those containing endostatin.
These cells express an endostatin binding protein.
Preferably endostatin is detected in a sandwich type assay format.
Isolation and characterization of the circulating form of human endostatin.
The use of endostatin in the treatment of solid tumors.
The synthetic peptide fragments of endostatin have a variety of uses.
Endostatin is a potent inhibitor of angiogenesis and blood vessel growth.
Antiserum against endostatin can be generated.
Endostatin is effective at causing regressions in a number of tumor models in mice.
Residual disease in endostatin treated mice.
Endostatin specifically and reversibly inhibits endothelial cell proliferation.
See also
It is to be understood that the endostatin can be animal or human in origin.
Such endostatin producing enzymes are also an aspect of the invention.
Such peptides are used in the isolation of the endostatin receptor.
It is anticipated that endostatin is made in cells of the nervous system.
Endostatin has several characteristics that may be advantageous to cancer therapy.
Isolation of human endogenous endostatin is accomplished using similar techniques.
There was no evidence of toxicity in any of the mice treated with endostatin.
It is possible that endostatin and angiostatin function in a similar fashion.
Angiogenesis inhibitors include but are not limited to endostatin and angiostatin.
Levels of endostatin in supernatant of HUVECs cells transfected with siRNA were measured.
Heparin column fractions with pure endostatin were pooled and frozen.
However endostatin alone has a poor predictive value for clinical usefulness.
Studies have demonstrated the role of endostatin in endometriotic lesions in animal models.
Endostatin is one of a growing list of such angiogenesis inhibitors produced by primary tumors.
Isolation and purification of the endostatin receptor is followed by amino acid sequencing.
The present invention also provides a method for quantitation of endostatin receptors.
Kits for measurement of endostatin are also contemplated as part of the present invention.
Herein described are methods of enhancing the sensitivity of target endothelial cells to endostatin.
Other studies relate the antiangiogenic use of endostatin for treating ocular neovascularization.
Also disclosed is a method of enhancing the sensitivity of target endothelial cells to endostatin.
This provides a useful tool to examine the effects of endostatin removal on metastatic processes.
Also disclosed is a kit comprising the reagents required to specifically measure endostatin.
The marker endostatin is used in the differential diagnosis of acute and chronic heart failure.
Nucleolin as marker for determining the likelihood of success of endostatin cancer therapy.
Endostatin and endostatin derived peptides can be coupled to other molecules using standard methods.
One strategy is the use of natural inhibitors of angiogenesis such as angiostatin and endostatin.
Endostatin and angiostatin are preferred agents for tumor delivery according to the present invention.
Also demonstrated is the effectiveness of endostatin derived from human for inhibiting tumor growth.
Endostatin is thought to bind an unidentified endothelial cell surface receptor that mediates its effect.
Such a bivalent structure may exhibit a higher binding affinity to the angiostatin or endostatin receptor.
The dormancy length achieved using a combination of endostatin and angiostatin far exceeds this criteria.
The peaks and valleys in the figure show the cycling effect of inhibition with endostatin.
These molecular probes provide means to detect and measure endostatin biosynthesis in tissues and cells.
Then endostatin levels were measured by ELISA in supernatants.
Tian identifies high levels of endostatin in rabbit ischemic tissue Tian et al.
