Examples of 'epothilone' in a sentence
Meaning of "epothilone"
'Epothilone' is an adjective used in chemistry to describe compounds that are structurally similar to taxanes and have potential anti-cancer properties.'
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- Any of various cytotoxic drugs.
How to use "epothilone" in a sentence
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epothilone
In particular the epothilone is formulated for perfusion.
Epothilone derivatives and their synthesis and use.
The present invention relates to epothilone derivatives.
The epothilone may be purified from fermentation broth.
Pharmaceutical formulations for parenteral administration comprising epothilone.
An epothilone compound may be provided in a highly purified form.
The inhibitor of mitosis may be epothilone.
The epothilone may also be administered by implantable dosing systems.
The invention is related to analogs of epothilone.
The principal mechanism of the epothilone class is inhibition of microtubule function.
A liposomal composition comprising an epothilone.
An example of an epothilone is iabepilone.
Both spontaneous activity and maternal behaviour were examined for test of epothilone effect.
The recombinant host cell may produce epothilone or an epothilone derivative.
Combination of an epothilone analog and chemotherapeutic agents for the treatment of proliferative diseases.
See also
Cloning and heterologous expression of the epothilone gene cluster.
This invention provides epothilone compositions which may exhibit an improvement in tolerability over free epothilone.
The invention relates to this new class of epothilone derivatives.
Propionate alone does not increase epothilone titers and at high concentrations can reduce titers.
The total time spent grooming was also highly significantly diminished by epothilone treatment.
This strain contains all the epothilone genes as well as all potential promoters.
The antimitotic agent disclosed herein but not claimed can also be an epothilone.
Yet another advantage is the ability to produce an epothilone derivative in a recombinant host cell.
Epothilone derivatives were already described by Höfle et al.
Others have also reported on the discovery of other epothilone derivatives and analogs.
Another synthesis of epothilone and epothilone derivatives was described by Nicolaou et al.
A flask containing CYE is inoculated with an epothilone producing strain.
Encapsulation of epothilone B is disclosed as specific example.
This graph is used to evaluate the POW value of the epothilone analogs.
Injection of DMSO after injection of the epothilone sample prevents precipitation in the tubing.
Colonies are screened using a probe from the NRPS region of the epothilone cluster.
The epothilone B product peak is collected in a number of fractions.
Summary of the Invention The present invention relates to methods for purifying an epothilone.
Standards were prepared using epothilone D purified from fermentation broth.
Also disclosed in the present invention is an improved process for the purification of epothilone B.
Cationic liposomes containing epothilone B were prepared according to the film method.
Increasing amounts of acetate in the fermentation media can increase Myxococcus growth and epothilone production.
The epothilone F product peak is fractionated to minimize closely eluting impurities.
The present invention provides crystalline forms of epothilone D.
Preferred is an infusion formulation comprising epothilone B and a pharmaceutically acceptable organic solvent.
Also disclosed is an improved process for the purification of epothilone B.
Several epothilone B analogues are also described there.
Feeding of propionate or sodium propionate produces significant improvement of epothilone B titers.
The ratio of epothilone C to epothilone D congeners may increase under depleted oxygen conditions.
The resulting crystals are preferably filtered to yield a primary grade epothilone B.
Figure 9 shows the stability of epothilone analogs in murine plasma.
In one aspect of the disclosure, therefore, the microtubule stabilizer is a taxane or an epothilone.
In the combination of the invention comprises epothilone B and ionizing radiation.
Examples of 3-cyano epothilone compounds and their preparation are provided below.
Standards were prepared using purified epothilone D.
