Examples of 'erbb' in a sentence
Meaning of "erbb"
Erbb is a noun that may represent an acronym, abbreviation, or a term specific to a particular context. Its meaning would depend on the field or subject it is associated with
How to use "erbb" in a sentence
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erbb
The four members of the ErbB family are.
The ErbB ligand may also be a synthetic ErbB ligand.
Neratinib is a potent irreversible pan erbB inhibitor.
Novel approaches for ErbB receptor tyrosine kinase inhibition.
They were then induced with the indicated ErbB ligands.
Methods for examining ErbB phosphorylation are known in the art.
An ErbB ligand gene thus may be obtained from a genomic library.
Carbohydrate moieties present on an ErbB ligand also are removed chemically or enzymatically.
The ErbB ligand may be recovered from a cellular membrane fraction.
The filters were hybridised successively with erbB and deltaPst probes.
Preferably the ErbB receptor is native sequence human ErbB receptor.
A heregulin variant according to the invention is capable of binding an ErbB receptor.
Inhibition of erbB signaling is a potent stimulus for the induction of apoptosis.
These compounds show inhibition activity against erbB family PTKs.
The ErbB receptor may be native sequence human ErbB receptor.
See also
The invention relates to increasing likelihood of effectiveness of an ErbB antagonist cancer treatment.
The ErbB receptor ligand to be used for in vivo administration should be sterile.
Chemical or enzymatic coupling of glycosides to ErbB ligand increases the number of carbohydrate substituents.
The selected ErbB receptor ligand may be administered continuously by infusion or by bolus injection.
Neuregulins are growth factors related to epidermal growth factors that bind to erbB receptors.
The prognostic importance of examining ErbB receptor family expression in human bladder cancer remains uncertain.
This mutation hence does not affect the transforming power of the erbB gene product.
ErbB protein family signaling is important for development.
This method requires the use of oligonucleotide probes that will hybridize to ErbB ligand.
The kit may also comprise components for detecting an ErbB activating mutation or gene amplification.
The invention also provides methods of ex vivo treatment of mammalian cells using ErbB ligand.
ErbB ligand optionally is fused with a polypeptide heterologous to ErbB ligand.
A novel technology capable of specifically detecting phosphorylation events in ErbB family RTKs has been developed.
Methods for determining ErbB and MET activity are described herein above.
This will involve the binding of growth factors associated with the ErbB signaling pathway.
ErbB receptor activation can be quantified using various tyrosine phosphorylation assays.
EGFR proteins are part of the ErbB family.
ErbB ligand may also be covalently modified by altering its native glycosylation pattern.
In some embodiments, the patient is resistant to treatment with an ErbB kinase inhibitor.
ErbB TMs may also have amino acids deleted or additional amino acids inserted.
Sustained-release compositions also include liposomally entrapped ErbB receptor ligand.
ErbB receptor phosphorylation can be quantified using the tyrosine phosphorylation assays described below.
Thus, the term includes per se ErbB receptor antagonists / inhibitors as defined above.
ErbB receptors and their ligands.
However, the significance of coexpression patterns of the ErbB receptor family remains controversial.
The ErbB Family.
Use according to claim 1 wherein the individual has an erbB protein-mediated brain tumour.
An “ ErbB dimer ” is a noncovalently associated oligomer that comprises two different ErbB receptors.
According to the invention, the antibody may inhibit the formation of the erbB dimers.
The ErbB receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin.
Various ligands which bind and / or activate such ErbB receptors have been described in the literature.
For instance, the erbB receptor protein can be immobilized utilizing conjugation of biotin and streptavidin.
For example, the heregulin variant can also have the ability to activate an ErbB receptor.
Therefore, disabling erbB receptors may improve the response to gamma-irradiation and other cytotoxic therapies.
The MluI sites were used to make constructs that expressed the desired ErbB receptor-Ig fusión.
