Examples of 'estetrol' in a sentence
Meaning of "estetrol"
Estetrol (noun): A hormone that is produced by the human fetal liver and is found in maternal urine and blood during pregnancy. It has been investigated for its potential medical applications, including its use as a treatment for menopausal symptoms and as an emergency contraceptive
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- 15α-hydroxyestriol, an estrogen steroid hormone produced by the human fetal liver during pregnancy only.
How to use "estetrol" in a sentence
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estetrol
Process for the production of estetrol intermediates.
Estetrol is excreted mostly or completely in urine.
No significant effect was observed for estetrol.
Estetrol has relatively minimal effects on liver function.
According to the invention the estrogenic substance is estetrol.
Drospirenone and estetrol combination is used to prevent pregnancy.
In a list of estrogens also estetrol is mentioned.
The synthesis of estetrol and derivatives thereof is known in the art.
Process for the preparation of estetrol.
These results show that estetrol has neuroprotective effect.
Minimal side effects have been observed with estetrol in women.
We therefore conclude that estetrol has a pharmacologically favourable profile.
Estetrol is an estrogen that is produced by the fetal liver during human pregnancy.
It is therefore concluded that estetrol has a pharmacologically favourable profile.
Estetrol is a biogenic estrogen that is endogenously produced by the fetal liver during human pregnancy.
See also
Without exception they all conclude that estetrol is a weak estrogen.
Estetrol is a biogenic estrogen that is endogeneously produced by the fetal liver during human pregnancy.
It is then washed with water and dried to give estetrol as a white solid.
They have found that estetrol can inhibit ovulation in rats and prevent pregnancy in rabbits.
The present invention relates to a new process for the synthesis of Estetrol.
Furthermore, estetrol is believed to be a very potent vasodilator.
Said method is not applied in a total synthesis of estetrol I.
Estetrol is metabolized minimally, if at all.
Most preferably, the estrogen is estetrol.
Structurally, estetrol is characterized by the presence of four hydroxyl groups.
In another preferred embodiment, the active ingredient is estetrol.
An example of the preparation of an estetrol containing intravaginal ring is set forth below,.
In further particularly preferred embodiments, the estrogenic substance is estetrol.
Therefore, it is difficult to isolate purified estetrol and intermediates thereof in good yield.
Recently, estetrol has been found effective as an estrogenic substance for use in HRT.
According to a particularly preferred embodiment, the liquid containing the estetrol is an aqueous liquid.
Example 8 An estetrol containing depot formulation can suitably be prepared as set forth below.
The following are non-limited synthesis examples for the synthesis of estetrol according to the invention,.
Estetrol is an agonist of the estrogen receptors ( ERs ), and hence is an estrogen.
In Example 3 the combined use of estetrol and lilopristone is mentioned.
Interestingly, estetrol dose-dependently reduced the number of pre-existing mammary tumours during the 4 week therapeutic trial.
The compound of formula ( I ) can then be further reacted to prepare estetrol.
Estetrol is a major metabolite of estradiol ( E2 ), formed from its precursors vía hydroxylation.
Figure 12 Brain weight of rat pups that were treated with estetrol.
Another type of estrogen is called estetrol ( E4 ), which is produced only during pregnancy.
Estetrol ( E4 ) is a natural oestrogen produced in large quantities by the human foetal liver.
Figure 5 Post-operative body weight of rat pups that were pre-treated with estetrol.
Funding to support Estetrol ( E4 ) and complex therapeutics solutions research projects.
Each tablet contained approximately 2.5 mg of estetrol.
Figure 14 Microtubule-associated protein 2 ( MAP2 ) staining of brain coronal sections in rat pups treated with estetrol.
