Examples of 'exendin' in a sentence
Meaning of "exendin"
exendin (noun) - A peptide drug used to regulate blood sugar levels in individuals with diabetes
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- Any of a group of peptide agonists found in Gila monster venom.
How to use "exendin" in a sentence
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exendin
Exendin agonists may be exendin analogs and derivatives.
Prodrugs comprising an exendin linker conjugate.
Exendin agonist formulations and methods of administration thereof.
There has been proposed ways of obtaining novel compounds by modifying the native exendin sequences.
Preferred exendin agonists are exendin analogs and derivatives.
IRMA was used to determine plasma exendin concentrations.
Various exendin agonist analogs are identified or referenced herein.
In one embodiment, the exendin agonist is a peptide.
Exendin for treating diabetes and reducing body weight.
However, they merely disclose several sequences of exendin analogs.
By exendin analog or derivative is meant a variant of the exendin molecule.
In addition, blood was drawn to assess plasma concentrations of exendin and glucose.
The exendin is administered subcutaneously.
In some embodiments, the zinc complex comprises an exendin or an analog thereof.
Exendins and exendin agonists for weight reduction and obesity.
See also
Use according to claim 19 wherein said exendin agonist is an exendin analog or derivative.
Activity as exendin agonists can be indicated by activity in assays described in the art.
Therefore, one object of the present invention is to provide exendin prodrugs with longer half-lives.
Doses of exendins or exendin agonists will normally be lower if given by continuous infusion.
More preferably, one application of the exendin hydrogel prodrug is sufficient for one week.
Exendins and exendin agonists are useful as described herein in view of their pharmacological properties.
Use according to claim 1 wherein said exendin or exendin agonist is to be administered continuously.
Exendin agonist compounds are those described in International Application No.
Specifically, hydrogels for the exendin prodrugs of the present invention are synthesized as follows,.
Exendin is commercialized as a therapeutic agent for diabetes, which is injected twice a day.
The obese mice had a similar food intake-related response to exendin as the normal mice.
Activity as exendin agonists can be indicated by activity in the assays described below.
The composition of claim 1, wherein the polypeptide is exendin.
Each of these exendin analogues and truncated analogues constitutes alternative embodiments of the present invention.
The composition of any of the claims 1 to 3, wherein the polypeptide is exendin.
Other novel exendin agonists are described in commonly owned PCT Application Serial No.
The use according to claim 1, wherein said exendin or exendin agonist peptide is exendin-4.
Novel exendin agonist compounds are described in commonly owned PCT Application Serial No.
In a particular embodiment, the peptide compounds are exendin peptides, including exendin-4 and analogs thereof.
Preferred exendins or exendin agonists for modification and use include,.
Still, there remains a need for development of long-acting exendin prodrugs with longer half-lives.
Preferably, said exendin or exendin agonist is administered subcutaneously.
A formulation according to Claim 1 wherein the exendin is exendin-4.
In one embodiment, the exendin or exendin agonist is administered subcutaneously.
Preferably the glucose-regulating peptide is a amylin peptide, an GLP-1 or a exendin peptide.
A preferred exendin agonist for modification and use includes,.
Another main object of the present invention is to produce an insulinotropic peptide, Exendin -4.
In one embodiment, the exendin or exendin analog agonist is continuously administered.
The GLP-1 compounds described herein also encompass Exendin compounds.
In some embodiments, the exendin or exendin analog agonists is given by chronic administration.
The GLP-1 compounds of the present invention also encompass Exendin compounds.
In other embodiments, the exendin or exendin analog agonist is administered by continuous mode.
In certain embodiments, the reference exendin is exendin-4.
Exendin compounds of this type have up to about forty-five amino acids.
Provided herein are exendin analogs wherein Xaa1 is His.
