Examples of 'exon skipping' in a sentence
Meaning of "exon skipping"
exon skipping - A molecular process in genetics where specific exons of a gene are excluded during mRNA processing. This phrase is commonly used in scientific discussions about gene expression and regulation
How to use "exon skipping" in a sentence
Basic
Advanced
exon skipping
In a preferred embodiment an exon skipping technique is applied.
An exon skipping molecule of the invention is preferably an isolated molecule.
In one embodiment an exon skipping technique is applied.
Exon skipping resulted in high levels of expression of dystrophin in the treated muscles.
We developed a technique called exon skipping for.
Induction of exon skipping in eukaryotic cells.
This is an example of exon skipping.
This type of exon skipping can be seen as splice correction.
That was when we started with the exon skipping technique.
Exon skipping techniques are nowadays explored in order to combat genetic muscular dystrophies.
Antisense oligonucleotides for inducing exon skipping and methods of use thereof.
Exon skipping is intended to allow for production of an internally truncated dystrophin protein.
The composition can be used to induce exon skipping of the respective exons.
The exon skipping technique can be used for many different purposes.
Agents capable of inducing specific exon skipping can be identified with a method of the disclosure.
See also
Exon skipping interferes with the natural splicing processes occurring within a eukaryotic cell.
Agents capable of inducing specific exon skipping can be identified with a method of the invention.
The unintentional removal of an exon from the final mRNA product is termed exon skipping.
This is distinguished from exon skipping because the retained sequence is not flanked by introns.
The suboptimal initiation codon preferably is an initiation codon that effects partial exon skipping.
Exon skipping is expected to serve as a method for treating DMD.
Sarepta investigational therapies in the ESSENCE study use a technique referred to as exon skipping.
The researchers will test the exon skipping approach in the new UCMD mouse model.
Exon skipping will change the fast Duchenne into the much slower Becker dystrophy.
In another embodiment, modulation of splicing is exon skipping.
Multiple exon skipping compositions for DMD.
In another part of the disclosure, modulation of splicing is exon skipping.
Antisense oligonucleotide-mediated exon skipping therapy of mdx mice.
The exon skipping molecule according to the invention, may be delivered as such.
We show the actual therapeutic effect of exon skipping for 7 different mutations.
Exon skipping is achieved in the nucleus during the maturation process of pre-mRNAs.
However, attempts to induce exon skipping using antisense molecules have had mixed success.
The concept of antisense oligonucleotide induced exon skipping is shown in FIG . 2.
However, the exon skipping molecule may also be encoded by the viral vector.
Methods for performing antisense oligonucleotide-mediated exon skipping in the retina of a subject in need thereof.
Thus, exon skipping can be induced by targeting the splice sites with antisense nucleic acids.
The concept of antisense oligonucleotide induced exon skipping is shown in Figure 2.
Accordingly, exon skipping can also be induced by targeting ESE.
Reference example, ERS-independent exon skipping.
Exon skipping therapy,.
The data presented in FIG . 7 demonstrate that exon skipping occurred in all conditions tested.
Thus, the observed exon skipping may be an intrinsic property of the human IRF-1 gene.
Single-stranded antisense oligonucleotides that can cause exon skipping of exon 58 was prepared and tested.
For now, Sarepta 's goal is pushing ahead with potentially viable treatments, exon skipping or otherwise.
TDP-43 is a nuclear protein involved in exon skipping and alternative splicing.
We refer to the correction of DMD mutations by exon skipping as myoediting . ”.
This nested PCR reaction will detect exon skipping of both exons 50 and / or exon 51.
Specifically, all the mutations induce exon skipping ( Figure 4 ).
You'll also be interested in:
Examples of using Exon
Show more
The target exon is not particularly limited
We developed a technique called exon skipping for
Each exon is represented with arrow marks
Examples of using Skipping
Show more
He was gonna start skipping things sooner or later
Skipping titles in forward direction or reverse direction
You have been skipping out on me all week
