Examples of 'farnesyl' in a sentence
Meaning of "farnesyl"
farnesyl (noun): A type of lipid molecule that plays a key role in cell signaling and cell structure, often associated with certain proteins and enzymes
Show more definitions
- The univalent radical derived from farnesol.
How to use "farnesyl" in a sentence
Basic
Advanced
farnesyl
Farnesyl pyrophosphate can be further converted to geranylgeranyl pyrophosphate.
A proposed biosynthesis starts with the farnesyl pyrophosphate.
Farnesyl and geranyl pyrophosphate also serve as precursors for prenylated proteins.
Farnesol is formed by dephosphorylation of farnesyl pyrophosphate.
The farnesyl pyrophosphate can bind to rubber transferase to elongate a new rubber polymer.
The compounds of the invention are useful as farnesyl transferase inhibitors.
Failure to remove this farnesyl group permanently affixes the protein to the nuclear rim.
The present invention relates to inhibitors of farnesyl protein transferase.
Ras farnesyl transferase inhibitors have been shown to have anticancer activity in several recent articles.
The cpm of product was considered to be farnesyl protein transferase activity.
Tocotrienol contains three repeating isoprene units giving rise to the farnesyl tail.
Its exact synthesis pathway from farnesyl pyrophosphate is still unknown.
Test compounds are added in adequate solvent and incubations start by addition of farnesyl transferase.
Farnesyl is necessary to attach Ras to the cell membrane.
The compounds are said to be useful for inhibiting farnesyl protein transferase.
See also
Inhibitors of farnesyl transferase based on mimicry of the CAAX box have been reported.
This enzyme catalyzes the reductive dimerization of two molecules of farnesyl pyrophosphate to form squalene.
The enzyme farnesyl protein transferase catalyzes the farnesylation of Ras by farnesyl pyrophosphate.
Parasites seem to be more vulnerable to inhibition of Farnesyl transferase than humans are.
Two molecules of farnesyl pyrophosphate condense with reduction by NADPH to form squalene squalene synthase.
Zingiberene is formed in the isoprenoid pathway from farnesyl pyrophosphate FPP.
The farnesyl group allows prelamin A to attach temporarily to the nuclear rim.
These compounds are then converted to farnesyl pyrophosphate by the action of FPP synthase.
Humulene is one of many sesquiterpenoids that are derived from farnesyl diphosphate FPP.
The compounds of this invention are potent Farnesyl Protein Transferase inhibitors having good pharmacokinetic stability.
Additionally, gliotoxin acts as an inhibitor of farnesyl transferase.
Examples of farnesyl transferase inhibitors include, lonafarnib.
Preferred terpenoid groups are farnesyl and geranyl-geranyl.
Other useful farnesyl protein transferase inhibitors have the structure,.
Once the protein is attached, the farnesyl group is removed.
There is a farnesyl functional group attached to the carboxyl-terminus of its structure.
PRIOR ART Processes for preparing farnesyl acetone are known in the prior art.
The compounds disclosed are inhibitors of in vitro protein, farnesyl transferase.
Pren represents a farnesyl or geranyl-geranyl group.
A compound of any of claims 1 to 8 for use in inhibiting farnesyl protein transferase.
Farnesyl transferase inhibitors, preparation thereof and pharmaceutical compositions containing same.
The compound of claim 1 for inhibiting farnesyl protein transferase.
The farnesyl group is an isoprenoid lipid moiety which is post-translationally added to proteins.
The enzyme reaction was started by adding 20 µl of diluted human farnesyl protein transferase.
The antiestrogen agent and the farnesyl transferase inhibitor may be administered simultaneously e . g.
Time course effect of the oligonucleotide antisense for the a-subunit of farnesyl transferase.
Two farnesyl pyrophosphate groups can also be combined to form squalene, the precursor for cholesterol.
Administering a radiation-sensitizing effective amount of a farnesyl protein transferase inhibitor before, during or after.
Advantageously, the farnesyl transferase inhibitor having a cytostatic activity can be administered according to a continuous scheme.
Mevastatine is an HMG-CoA reductase inhibitor which blocks the synthesis of farnesyl metabolic precursors.
Farnesyl pyrophosphate synthase ( FPPS ) is a key regulatory enzyme in the mevalonate pathway.
Modifying lipid groups include, but are not limited to, farnesyl groups and myristoyl groups.
Farnesylation of Ras by farnesyl pyrophosphate ( FPP ) is effected by protein farnesyltransferase.
Last year, the team discovered that a single protein converts farnesyl diphosphate to geosmin.
In vitro enzyme assays, Inhibition of farnesyl protein transferase and geranylgeranyl protein transferase.
