Examples of 'fgfs' in a sentence
Meaning of "fgfs"
fgfs (noun) - This term doesn't have a standard definition in English. It could be an acronym or a specialized term in a specific field
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- plural of FGF
How to use "fgfs" in a sentence
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fgfs
Each receptor can be activated by several FGFs.
The FGFs produced a profound chemotactic response in HDFs.
Wnt signaling activated by FGFs is responsible for this movement.
The compounds according to the present invention also inhibit FGFs.
Preferably the FGFs are to be applied locally to stimulate periosteal bone formation.
Also provided are methods of manufacturing the modified FGFs and pharmaceutical compositions described herein.
The modified FGFs described herein are uniquely suited for application in the eye.
The bioactivity of individual GAGs chains for FGFs is closely related to carbohydrate chain length.
These FGFs also appear to play important roles in both developing and adult tissues.
Inappropriate expression of some FGFs can contribute to the pathogenesis of cancer.
Such cells will enable one to analyze the binding properties of various native FGFs.
Aberrant expression of FGFs may cause cell transformation by an autocrine mechanism.
Wellstein and colleagues found that this chaperone binds to three FGFs that help regulate metabolism.
Methods for producing FGFs using genetic engineering techniques are known.
Each FGFR binds to a specific subset of the FGFs.
See also
The expression of FGFs suggests that they have an important role in development.
Phase I and II clinical trials with VEGFs and FGFs have been started.
The KGFs are unique among FGFs in that they act exclusively on epithelial cells.
FGFs are also important for maintenance of the adult brain.
The amino acid sequences of exemplary human FGFs are,.
Similarly most FGFs can bind to several different FGFR subtypes.
As used herein, the term HBGFs includes all FGFs.
FGFs also have a high affinity for heparin sulfate proteoglycans.
In particular, activity of the HBBMs was compared with that of the FGFs.
FGFs fail to bind and activate FGF receptors in cells deprived of endogenous heparan sulfate.
As well as stimulating blood vessel growth, FGFs are important players in wound healing.
FGFs also exhibit potent angiogenic activities.
In some embodiments, the modified FGFs or compositions described herein may be prepared as prodrugs.
FGFs are active in many different biological processes, in addition to helping regulate metabolism.
In other embodiments, a combination of one or more modified FGFs described herein can be administered.
Other FGFs may also work, even if at higher concentrations.
The FGF polypeptides include those from other species besides humans, including murine FGFs.
Thus, FGFs could play a role in nociception and chronic pain.
FGFR-2 also propagates the potent osteogenic effects of FGFs during osteoblast growth and differentiation.
Thus, FGFs are major determinants of neuronal survival both during development and during adulthood.
While VEGF is specific for endothelial cells, FGFs also stimulate smooth muscle cell growth.
Many FGFs bind their respective FGFRs with very high affinities, some in the picomolar range.
Alternatively, the secreted FGF receptors may serve to store and sequester FGFs at a particular location.
Between vertebrate species, FGFs are highly conserved in both gene structure and amino-acid sequence.
Table 1 lists some of the known FGF-FGFR signaling relationships of various FGFs and their FGFRs.
During embryonic development, FGFs have diverse roles in regulating cell proliferation, migration and differentiation.
It seems likely, therefore, that KGF acts through a different cell surface receptor than the FGFs.
FGFRs bind to FGFs to form dimers, and are activated by phosphorylation.
Twelve structurally conserved anti-parallel B strands have been identified in all the FGFs.
FGFs have been implicated in bone formation, affecting osteoprogenitor cell replication, osteoblast differentiation, and apoptosis.
The extracellular domains of FGFRs ( defined below ) bind to one or more FGFs.
FGFs stimulate cells by interacting with cell surface tyrosine kinase receptors ( FGFR ).
Furthermore, the HBBM-3 and its activity were separable from the FGFs.
FGFs function as growth factors by binding and thereby activating cell-surface FGF receptors.
FGF19 is a member of the most distant of the seven subfamilies of the FGFs.
