Examples of 'filaggrin' in a sentence
Meaning of "filaggrin"
filaggrin (noun) - a structural protein found in the outermost layer of the skin. Filaggrin plays a crucial role in maintaining the skin's barrier function and hydration levels, and its deficiency is associated with certain skin conditions like eczema
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- A filament-associated protein that binds to keratin fibres in epithelial cells
How to use "filaggrin" in a sentence
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filaggrin
Filaggrin binds to keratin fibers in epidermal cells.
Protective and soothing action thanks to filaggrin precursors.
Recombinant filaggrin polypeptides for cell importation.
This application describes an antigen comprising a filaggrin or profilaggrin fragment.
The synthesis of filaggrin by human epidermal keratinocytes.
We also know there is an emphasis on epidermal barrier dysfunction with filaggrin mutations.
Filaggrin is essential for the regulation of epidermal homeostasis.
Thus the basic protein filaggrin has been identified as a target antigen.
Filaggrin is important for formation of the skin barrier.
Researchers have discovered that a lack of filaggrin could contribute to the onset of eczema.
Filaggrin staining is appropriately limited to the granular layer.
All of the mutations assessed would cause the filaggrin gene not to work.
The production of filaggrin by was evaluated by immunolabeling.
Further embodiments include a nucleic acid that encodes a filaggrin amino acid sequence.
Filaggrin plays a key role in the corneification process.
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A person with atopic dermatitis often has a genetic mutation in a protein in their skin called filaggrin.
A lack of filaggrin dries and weakens the skin barrier.
One of the main proteins that accumulate within lipofuscin granules is Filaggrin.
Filaggrin is also involved in maintaining the water content of the corneal layers.
The amino acids resulting from the decomposition of filaggrin are described by MANSBRIGE in Arch.
Filaggrin is a family of proteins which has been identified in various species in keratinizing epithelia.
The researchers looked for two filaggrin mutations that are the most common among Europeans.
Filaggrin is a protein that is essential for skin hydration and integrity of the skin barrier.
Conditions associated with aberrant filaggrin and NMF production include Ichthyosis Vulgaris.
Filaggrin gene defects also increase the risk of asthma in people with atopic eczema.
The level of expression of filaggrin is perturbed, as is that of involucrin.
The filaggrin amino acid sequence is any filaggrin amino acid sequence as set forth herein.
Normally, every cell in the skin has two copies of the filaggrin gene.
A mutation in filaggrin results in a breakdown of the barriers between epidermal skin cells.
Upon terminal differentiation of granular cells, profilaggrin is proteolytically cleaved into filaggrin peptides.
Quantitative filaggrin deficit and the inflammatory response triggered by the immune system.
The protein fraction consists of epidermally derived proteins, primarily keratin and filaggrin.
Antigens derived from filaggrin and their use for diagnosing rheumatoid polyarthritis.
Autoantibodies in rheumatoid arthritis recognizing an epitope of citrullinated peptides are cross-reactive with filaggrin.
A significant association between filaggrin mutations and eczema was shown in familes affected by ichthyosis vulgaris.
As epidermal cells mature, they produce the keratin filament-aggregating protein known as filaggrin.
Recombinant filaggrin is produced according to the following protocol,.
This cleavage first generates fragments of intermediate size, and then the functional molecules of filaggrin.
Study of expression of filaggrin and claudin 1 and 4 in adults with atopic dermatitis dissertation.
Genetic predisposition and / or an immune anomaly is often put forward ( for example a filaggrin deficiency ).
Filaggrin is a protein naturally present in the upper layer of the skin, the epidermis.
Expression of the corneocyte structural protein loricrin, filaggrin and involucrin increase during this period.
Filaggrin ( filament aggregating protein ) is a filament-associated protein that binds to keratin fibers in epithelial cells.
Natural moisturizing factors include the water-binding, metabolic by-products of skin proteins, especially filaggrin.
Examples of filaggrin sequences are set forth in Table 2 below.
FIG . 19 shows that the sera of patients suffering from RA specifically recognize human filaggrin.
Filaggrin subsequently undergoes proteolysis within the corneocyte to form natural moisturizing factor ( NMF ).
The oligonucleotide has at least 90 % sequence identity to a complement of a Filaggrin ( FLG ) natural antisense transcript.
Treatment of filaggrin ( FIG ) related diseases by modulation of FIG expression and activity.
Yet, there was an evolutionary tradeoff for these barrier-weakening filaggrin mutations, Elias said.
