Examples of 'follistatin' in a sentence
Meaning of "follistatin"
follistatin (adjective): Relating to or characteristic of follistatin, a binding protein capable of regulating biological activity. In English, this term might be used to describe properties or qualities associated with follistatin or its functions
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- A protein that binds to, and neutralizes, activin
How to use "follistatin" in a sentence
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follistatin
Changes in serum follistatin levels were not observed.
Follistatin is another protein that acts as a myostatin inhibitor.
Process for producing active follistatin.
Lack of follistatin results in reduced muscle mass at birth.
Process for producing a composition containing active follistatin.
Levels of follistatin were measured monthly.
Changes in myostatin and follistatin.
Follistatin of which it is a variant or mutant.
Blocking activin action by exogenous follistatin reduces the subsequent damage.
The follistatin polypeptide contains the heparin sulfate binding site.
Increasing the functional level of follistatin should be understood to have a converse meaning.
The follistatin for use in the invention may alternatively be produced as a fusión protein.
The present invention also includes fusions of follistatin with other molecules.
The amount of follistatin secreted from each clone was determined.
Experiments examining the effect of delivering follistatin using a rAAV are described below.
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A recombinant follistatin protein described herein can be formulated as neutral or salt forms.
Preferably the graft is treated with the activin inhibitor or follistatin prior to transplantation.
These results indicate that follistatin is a potent and specific inhibitor of myostatin and activin activity.
The factor may be applied simultaneously or immediately following application of the cells expressing follistatin.
A recombinant follistatin protein suitable for the present invention may be produced by any available means.
This example demonstrates that protein therapeutics can also be developed based on follistatin variants.
The recombinant follistatin protein of the invention is fused to an Fc domain.
The transformed cell is then cultured under conditions that allow expression of the follistatin protein.
The recombinant follistatin protein of the invention is fused to the Fc domain vÃa a linker.
The effects of the application of the drug Follistatin.
Exemplary data for the circulating levels of follistatin after administration is shown in FIG.
Follistatin is now thought to be an inhibin / activin binding protein.
Increase in Follistatin levels.
For example, the myostatin inhibitor is follistatin.
Linker or Spacer A follistatin domain may be directly or indirectly linked to an Fc domain.
According to the invention, said graft is pretreated with said inhibitor or follistatin.
Follistatin for use in down-regulation an inflammatory response.
In some embodiments, the recombinant follistatin protein is administered systemically.
Follistatin is an autocrine-glycoprotein that is expressed in nearly all tissues of higher animals.
Therefore, expression of follistatin mRNA serves as a marker of protein synthesis.
Yet more preferably, said graft is pretreated with said inhibitor or follistatin.
Typically, a recombinant follistatin protein is produced using recombinant technology.
When used in the treatment of a pulmonary fibrosis, the follistatin may be administered alone.
In contrast, follistatin expression was elevated initially relative to normal levels.
Typically, these prodrugs are functional derivatives of follistatin which are readily converted in vivo.
In addition, serum follistatin levels were increased following subcutaneous injection.
Typically, administration results in delivery of a recombinant follistatin protein to one or more target tissues.
Figure 4 shows follistatin expression in fibrotic animal liver section by immunohistochemistry.
A prominent antagonist of the members of the TGFB-BMP family is follistatin.
In some embodiments, the recombinant follistatin protein is delivered to the heart.
For example, follistatin domain deletions or point mutations may retain or improve muscle regeneration efficacy.
In some embodiments, the recombinant follistatin protein is delivered to skeletal muscle.
All follistatin constructs used in this example contain a GAG3 linker.
Alternatively or additionally, a recombinant follistatin protein may be produced by activating endogenous genes.
Activin A occurs naturally in free form and in bound form, bound to a protein called follistatin.
