Examples of 'forms of compound' in a sentence
Meaning of "forms of compound"
forms of compound - Different types or variations of compounds, which are substances composed of two or more elements
How to use "forms of compound" in a sentence
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forms of compound
He is known for having invented three important forms of compound locomotive.
Forms of compound A were applied on an acid equivalent basis.
The data demonstrate that bioavailability can be increased by using salt forms of compound no.
The polymorphic forms of compound A were characterized using the following procedures.
The present invention includes salt forms of Compound A as obtained.
No crystalline forms of compound 1 have previously been reported.
The present disclosure provides certain such solid forms of Compound I.
We have found that the certain crystalline salt forms of Compound I possess advantageous pharmaceutical properties.
Figure 7 provides scanning electron micrographs of the hemisuccinate salt forms of compound 1.
Additional crystalline forms of Compound I are also further described herein.
The structure depicted for compound 2 is also meant to include all tautomeric forms of compound 2.
Also disclosed herein are solid forms of Compound 1 or a pharmaceutical salt thereof.
Accordingly, the present invention provides both free base forms and salt forms of compound 1.
All such solid forms of Compound 1 are contemplated by the present invention.
Further object provides the process for the preparation of pure forms of compound 6 and compound 7.
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Salts and crystal forms of Compound 1 have been prepared as described in the following examples.
The relative stabilities of the polymorphic forms of Compound 1 were analyzed.
The crystalline forms of Compound ( I ) difumarate described herein are crystalline.
In particular it was the objective to provide new crystalline solid forms of compound ( I ).
In some embodiments, such forms of Compound I may be a solvate.
The invention includes all pharmaceutically acceptable salt forms of Compound 1.
The crystalline forms of Compound ( I ) can be obtained from a supersaturated solution.
Also included are ways to prepare the salts and crystalline forms of Compound 1.
In one embodiment, solid forms of Compound I described herein possess improved properties.
Figure 2 provides DSC plots of the hemifumarate and hemisuccinate salt forms of compound 1.
Examples of some isomeric forms of compound 1 are shown below,.
Similar methods can be used to make crystalline polymorphic forms or amorphous forms of Compound 2.
The crystal forms of compound ( 1 ) of the present invention have excellent water-solubility and thermal stability.
The composition may comprise micronized crystalline polymorphic forms or amorphous forms of Compound 1 or Compound 2.
Accordingly, the solvate crystal forms of compound of formula ( X ) are optionally milled after undergoing conversion.
The present disclosure also describes amorphous forms of Compound 1 or Compound 2.
Among these crystalline forms of Compound ( I ), crystalline forms of hydrates are preferred.
In certain embodiments, the solid forms are single-component crystal forms of Compound A.
Forms of compound 1 or compound 2 were applied on an acid equivalent ( ae ) basis.
Example 1 describes the preparation of the benzoate, toluenesulfonate and hydrochloride salt forms of Compound I.
Forms of compound A ( compound of formula I ) tested include,.
Form XXV has several unexpected advantages over previously discovered crystalline forms of Compound 1.
In various embodiments, salts and crystalline forms of Compound 1 are provided.
Described herein is Form A of Compound 1 comprising one or more additional solid forms of Compound 1.
The present disclosure also provides amorphous forms of Compound 1 or Compound 2.
A " pure " polymorphic form contains no PXRD-detectable amount of any other physical forms of Compound 1.
In one aspect, described herein are solid forms of Compound I.
In some embodiments, a composition can include Form A with one or more other forms of Compound I-1.
Applicants describe herein five novel solid forms of Compound I-2.
The inventive polymorphs of Compound 13 are, preferably, essentially free of other forms of Compound 13.
Figure 12 tabulates a single crystal structure summary for solid forms of Compound I . DEFINITIONS.
The Figures show the XRDP of the following salts and salt forms of Compound A,.
The solid forms can be solvates, hydrates and unsolvated forms of compound 2.
Figure 6 provides the XRPD plots of the hemisuccinate salt forms of compound 1.
Form B of Compound 1 may be substantially free of other forms of Compound 1.
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