Examples of 'fumarate salt' in a sentence
Meaning of "fumarate salt"
fumarate salt: a compound formed by the reaction of fumaric acid with a base, commonly used in pharmaceuticals
How to use "fumarate salt" in a sentence
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fumarate salt
It was crystallized as the light yellow fumarate salt.
The product fumarate salt was recrystalized from isopropanol.
It has been almost exclusively formulated as the fumarate salt.
The fumarate salt can then be obtained by subsequent crystallization.
It is present in tablets as the fumarate salt.
The fumarate salt was formed.
Quetiapine fumarate is present in tablets as the fumarate salt.
As the fumarate salt.
It was crystallized as the white fumarate salt.
The fumarate salt was obtained from an ethanol solution by addition of fumaric acid.
This product was solidified by formation of the fumarate salt.
Tenofovir disoproxil fumarate is the fumarate salt of the prodrug tenofovir disoproxil.
The suspension was cooled and filtered to provide the fumarate salt.
The hydrochloride salt and the hydrogen fumarate salt are particularly preferred.
The racemic mixture that is commercially available for administration is a dihydrate of the fumarate salt.
See also
The precipitated aliskiren fumarate salt was filtrated and dried giving the product.
Typically a base is directly added as a neutralizing agent and a fumarate salt is formed.
The free base was converted into its fumarate salt which was recrystallised from methanol.
In some embodiments, the compound is a fumarate salt.
Thus, the fumarate salt was selected for further work.
After cooling in a refrigerator overnight the precipitated fumarate salt was filtered off and dried.
The fumarate salt as claimed in claim 1 for use as a medicament.
The inventors have also found that the fumarate salt obtained may be further purified.
The fumarate salt of the above compound was prepared as follows,.
This is converted into its fumarate salt as described above ;.
The fumarate salt of the title compound 3a crystallized from ethanol.
Preferred embodiments comprise formoterol 2 as its fumarate salt and / or as a dihydrate.
Preferably, the fumarate salt is formed in isopropanol with subsequent crystallisation of the desired polymorph.
Upon heating the title compound 3 crystallized as the fumarate salt.
The fumarate salt was prepared by the method of Example 2.
Hence, the solubility of succinate was in all instances higher than the fumarate salt.
The fumarate salt of a compound of Formula 5a exists in certain crystalline forms.
In another embodiment the compound of Formula 5 is isolated as a fumarate salt.
One pharmaceutical comprises a fumarate salt of a compound of Formula 5a with mannitol.
A process according to Claim 5 wherein the compound of Formula 5 is isolated as a fumarate salt.
Another pharmaceutical composition comprises a fumarate salt of a compound of Formula 5a, mannitol and dicalcium phosphate.
Summary of the invention In a first aspect, the present invention concerns a fumarate salt of solifenacin.
In particular a fumarate salt of a compound of Formula 5a is in crystalline Form A.
We have now discovered a novel formulation comprising a fumarate salt of a compound of Formula 5a.
The fumarate salt was obtained by dissolving the compound in MeOH in presence of 0.9eq.
An embodiment of the present invention comprises the fumarate salt of formula ( XIII ).
The amine was converted into the fumarate salt and recrystallized in ethanol, isopropyl ether, m . p.
In the foregoing drug concentrations are given as ( w / v ) and as fumarate salt.
Crystallization as the fumarate salt from isopropanol / ether gave the title compound in 210 mg yield.
A process according to any of claims 1 to 4 wherein said salt is a fumarate salt.
In some embodiments, the salt is a fumarate salt such as Compound 3.
In one embodiment the compound of Formula 5 is isolated as a di-phosphate, D-tartrate or fumarate salt.
In contrast, the appearance of the fumarate salt of the compound of formula ( I ) remains unchanged.
Ether was added to the decantate and 4.0g of a white fumarate salt was collected.
The base was converted to the fumarate salt according to the procedure described for Example 103.
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Examples of using Fumarate
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With tenofovir disoproxil fumarate or with emtricitabine
Fumarate is also a product of the urea cycle
It oxidizes succinate to fumarate and reduces ubiquinone
