Examples of 'gain-of-function' in a sentence

Meaning of "gain-of-function"

Gain-of-function refers to genetic changes that result in a gene or protein having an enhanced or new activity, often leading to a change in the phenotype of an organism. This term is commonly used in genetics and molecular biology
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  • Alternative form of gain of function

How to use "gain-of-function" in a sentence

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gain-of-function
Many of these mutations have been shown to be oncogenic gain-of-function mutations.
Gain-of-function mutations create a new allele that is associated with a new function.
The phenotypes in our transgenic mice are probably caused by a gain-of-function mechanism.
Their normal function is altered by gain-of-function mutations associated with cancer diseases.
The present invention relates to novel methods for treating dominant gain-of-function disease.
Some of these are gain-of-function mutations which are necessary for the transformed phenotype.
The genetic model for this disease is gain-of-function.
The rational for gain-of-function studies is twofold.
However, there are examples of insertions generating gain-of-function mutations.
Gain-of-function mutations drive constitutive NF-κB activation in both types of cells.
Rna interference for the treatment of gain-of-function disorders.
By contrast gain-of-function alleles convert antennae into ectopic legs.
This has been achieved in part through controversial gain-of-function research.
Genes whose gain-of-function alterations lead to neoplastic cell transformation.
In one embodiment, the siRNA is targeted to the gain-of-function mutation.

See also

Such gain-of-function can be explained by any dominant negative mechanism.
Oncogene mutations, in contrast, generally involve a single allele because they are gain-of-function mutations.
One gain-of-function mutation is different and results in a protein with a ‘ new function '.
Two of the most common types of manipulation experiments are loss-of-function and gain-of-function experiments.
A dominant-negative or deleterious gain-of-function mutation can occur if premature terminating ( nonsense ) codons are translated.
This has been achieved in part through controversial gain-of-function research . Of note were.
In contrast, XLN is due to gain-of-function mutations, and patients suffer from severe neutropenia.
As a result, they proposed the hypothesis that FXTAS results from an RNA toxic gain-of-function.
The gain-of-function mutations of the KCNT1 gene are the main causes of this epilepsy.
Months ago, while conducting illegal gain-of-function studies.
The germline and somatic gain-of-function STAT3 mutations appear to result in distinctly different phenotypes.
The use of claim 1, wherein the cell has a hedgehog gain-of-function phenotype.
Some gain-of-function mutations in the VWF A1 domain may increase the affinity for GpIba.
The allele frequency of PCSK9 gain-of-function mutations is rare.
Gain-of-function experiments overexpressing FOXP3 in Tconv resulted in a reduced expression of SATB1 Fig.
The mutant protein may be a gain-of-function mutant or a loss-of-function mutant.
A gain-of-function mutation causes platelet-type von Willebrand 's disease.
In some embodiments, the individual has a gain-of-function PCSK9 gene mutation.
Gain-of-function mutations in KRAS and BRAF genes are found in up to 50 % of colorectal cancers.
Both Ebright and Wain-Hobson are long-standing critics of gain-of-function research.
The R102C allele showed gain-of-function activities by potentiating these effects.
Figures 4A-H illustrate phytohormone-independent somatic embryo formation caused by the pga6 gain-of-function mutation.
Gain-of-function mutations in the phosphatidylserine synthase 1 ( PTDSS1 ) gene cause Lenz-Majewski syndrome.
The method of claim 6, wherein the somatic gain-of-function mutation is a deletion from exon 19 of EGFR.

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