Examples of 'galanin' in a sentence
Meaning of "galanin"
galanin (noun) - a neuropeptide that is found in the brain and plays a role in regulating various physiological functions. This term is often used in the context of neuroscience and neurobiology
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- A particular inhibitory neuropeptide
How to use "galanin" in a sentence
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galanin
As a first step the murine galanin gene was cloned.
Galanin hyperpolarizes and decreases membrane excitability in most parasympathetic neurons.
They were particularly interested in the impact of galanin on neutrophil function.
Galanin is located predominantly in the central nervous system and gastrointestinal tract.
A promising new approach to treating seizures is to target a molecule called galanin.
They also discuss whether galanin may play a role in depressive diseases.
The peptides of the invention proved to bind specifically to the galanin receptor.
The present invention relates to a galanin antagonist which is a galanin receptor ligand.
The presence of functional receptor may be confirmed by performing binding assays using labeled galanin.
A handful of studies have suggested that galanin has a role in stress and anxiety.
Rat and porcine galanin resulted in indistriguishable displacement curves with the membranes from rat hypothalami.
The data demonstrated the antinociceptive effect of the galanin fusión proteins of the present invention.
Doses of each molecule administered were varied to give near molar equivalent Galanin doses.
There is increasing evidence that galanin like NPY has antidepressant effects.
It was developed by Denis Galanin.
See also
Accordingly, antagonists of galanin facilitate seizures in these models.
Specific binding was defined as that displaceable by 1 µM galanin.
Galanin exerts its effects by binding to membrane-bound receptors.
Nonspecific binding was estimated in the presence of 1 µM of unlabeled galanin.
Hitherto no galanin antagonists, which are galanin receptor ligands, have been reported.
In this regard, particular reference is made to galanin and derivatives of galanin.
Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways.
A method according to claim 35 wherein said anorectic agent is a galanin antagonist.
Furthermore, mice deficient in galanin are unable to recruit neutrophils following an inflammatory stimulus.
Mechanisms underlying the seizure-suppressant effects of galanin are not well understood.
Galanin has a widespread distribution in the peripheral and central nervous systems, gut and pancreas.
Such antagonism is not specific for galanin action, and is not exerted at galanin receptor.
In yet another embodiment, the retargeted endopeptidase activity being detected is from a galanin retargeted endopeptidase.
LIF, galanin and nitric oxide suffer upregulation.
The transfected cells were exposed to varying concentrations of different galanin fusión proteins for 24 hours.
Galanin has been implicated in the aetiology of Alzheimer 's disease.
This invention also provides an isolated galanin GALR2 receptor protein.
In contrast, Galanin linked to the Fc alone was unable to provide effective pain relief.
Galmic is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.
Furthermore, targeted disrupttion of galanin gene increases seizure susceptibility in SE, kainate and PTZ models.
The invention also encompasses fragments, variants, and derivatives of the galanin TM described above.
Galanin, galanin receptor subtypes and depression-like behaviour.
Development of a cell-based assay for a galanin re-targeted endopeptidase.
Galanin ( gal ) is a peptide present in the cns of various mammals, including human being.
Specific binding was defined as that displaceable by 1 µM galanin ( or appropriate concentration of a displacer ).
Galanin is predominantly an inhibitory, hyperpolarizing neuropeptide [ 1 ] and as such inhibits neurotransmitter release.
Two cosmid clones were identified spanning 60Kb around the galanin locus.
Various galanin related peptides were used in competition experiments performed using 125I-galanin as a tracer.
In an embodiment, such other galanin receptor is a GALR1 receptor.
We have also acquired commercially AAV serotype ½ vectors expressing NPY, Y2, and galanin.
In an embodiment, the other galanin receptor is a GALR1 receptor.
Galanin is a 29 amino acid neuropeptide which was first isolated from porcine intestine in 1983.
In another embodiment, such other galanin receptor is a GALR3 receptor.
The Franz Kafka Videogame was developed over a period of 2.5 years, by Denis Galanin.
First publications on galanin gene transfer in experimental epilepsy models appeared in 2003 Haberman et al.
