Examples of 'galnac' in a sentence
Meaning of "galnac"
Galnac is a type of sugar molecule commonly found in glycoproteins
How to use "galnac" in a sentence
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galnac
Described is that the ligand is a GalNAc ligand.
Identification of the GalNAc kinase amino acid sequence.
Such a conjugate is also referred to herein as a GalNAc conjugate.
Other GalNAc synthons suitable for coupling to sTNFR were described in the literature.
Processes for the preparation of galnac acid derivatives.
In preferred embodiments the galactose moiety transferred by CgtE is GalNAc.
The corresponding number of incorporated GalNAc units is indicated in brackets.
Trivalent GalNAc conjugates may be used to target the compound to the liver.
This suggest that this gene encodes the GalNAc transferase.
Other GalNAc synthons suitable for coupling to various proteins were described in the literature.
One approach was based on the synthesis of a glycolipid containing terminal GalNAc residues.
In a preferred embodiment the GalNAc derivative has the formula Ia wherein n is as above.
Such compounds are much easier to prepare than conjugates comprising three GalNAc ligands.
The conjugation with the GalNAc acid salt of formula V is preferred.
The hepatic lectin binds to glycoproteins containing either nonreducing terminal GalNAc or galactose.
See also
Optionally to transform GalNAc acid salt of formula V into the GalNAc acid derivative of formula I.
The addition of sialic acids to terminal Gal or GalNAc is mediated by sialyltransferases.
These cells will express and secrete sTNFR in which Gal residues are replaced by GalNAc.
For example a GalNAc-Gal residue is trimmed back to GalNAc.
Concentration of the selected fractions from the chromatography provides a pure GalNAc acid salt of formula V.
Alternatively, GalNAc can be added chemically to a soluble scavenger receptor.
In a preferred embodiment, the galactose moiety is GalNAc.
In an exemplary embodiment, a GalNAc residue is added by the action of a GalNAc transferase.
In some embodiments, the ligand is a GalNAc ligand.
Alternatively, GalNAc can be added chemically to sLDLR or to its related homologous.
Also, the first monosaccharide added need not be GalNac.
Furthermore, the GalNAc conjugate group did not have a significant effect in this assay.
In these cases, it is advantageous to add the initial GalNAc moiety in vitro.
As used herein GalNAc and represents an N-acetylgalactosamine residue.
The process of the invention can be conducted up to any desired GalNAc transfer %.
Synthesis of 3 ′ GalNAc conjugated single strands was performed on a GalNAc modified CPG support.
Alternatively, an unmodified Gal can be added to the terminal GalNAc residue.
CgtE was observed to transfer both Gal and GalNAc residues to a terminal a-Gal residue.
The formed GalNAc N-hydroxysuccinimid ester was used without further purification for conjugation to RNA.
Alternatively, sTNFR may be expressed in a system that incorporates GalNAc to the N-glycan moiety.
In vitro GalNAc transfer to MUC6 proteins.
The first is the addition of the terminal GalNAc ( lgtD ).
In some embodiments, the GalNAc conjugate is linked at the 5 ′ end of the oligomer.
The dsRNA of claim 6, wherein said ligand is a GalNAc ligand.
The GalNAc derivatives can be attached vía a linker, e.g., a bivalent or trivalent branched linker.
The method of claim 27, wherein the GalNAc cluster is a trivalent GalNAc cluster.
The reaction mixture of claim 30, wherein the acceptor saccharide comprises a terminal GalNAc residue.
Example 9, Incorporation of GalNAc lipids into liposome formulations.
This may be linked to tetrasialylation and potency because the 2,6 - sialylation is associated with GalNac.
In certain embodiments, the carbohydrate cluster portion comprises 4 GalNAc groups and is designated " GalNAc4 ".
GalNAc was first added to the interferon through the activity of the MBP-GalNAc-T2 enzyme.
These saccharides also have a reducing terminal monosaccharide residue, typically GlcNAc or GalNAc ( N-acetyl-galactosamine ).
Figure 5, Examples of GalNAc conjugates of the INA compounds.
The antisense oligonucleotide conjugate according to claim 4, wherein the conjugate moiety ( C ) comprises a tri-valent GalNAc moiety.
GalNAc refers to the structure in formula ( IV ).
