Examples of 'germ-line' in a sentence
Meaning of "germ-line"
germ-line (noun): Germ-line refers to the lineage of cells that lead to the formation of eggs or sperm in an organism. It is the genetic material that is passed down from generation to generation
How to use "germ-line" in a sentence
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germ-line
Certain mutations responsible for cancer are germ-line.
The duplicated germ-line chromosomes are called sister chromatids.
An individual may of course inherit two different germ-line mutations.
The moral evaluation of germ-line cell therapy is different.
Germ-line tissue can occur in any tissue and are inherited.
The likely association of germ-line therapy with cloning technologies.
Germ-line mutations are passed from the parent to the offspring.
Positive mice were bred to test germ-line trasmission of the transgene.
Meiosis is just one step in the life cycle of a germ-line cell.
One important kind of externality in germ-line enhancements is their effects on social equality.
In any case, mitochondrial transfer does not necessarily entail germ-line engineering.
Inherited or germ-line mutations, which are abnormal genes that a person is born with.
The residues altered to human germ-line are shown as bold font.
When we speak of mutations in multicellular organisms, we are usually talking about germ-line mutations.
Such techniques have the advantage that germ-line transgenic animals are readily produced.
See also
Often, at least one of the exchange cassettes is identical to a human germ-line sequence.
The germ-line is the tissue within the reproductive organs that produces the gametes.
The cells that undergo meiosis to produce the gametes are called germ-line cells.
These sequences will be introduced into the germ-line via the same mechanism as a knock-out.
WFA Germ-line therapy is a technique forbidden to most of the world 's scientists.
Sequence analysis revealed that three different germ-line VH gene segments were used.
Germ-line DNA repair mutations that increase the risk of cancer are listed in the Table.
They have been used as a phenotypic marker for germ-line V genes.
We also confirmed the germ-line transmission in independent founder mice of Foxnl Fig.
I am also pleased, however, that we have succeeded in clamping down on germ-line gene therapy.
The DNA inside a germ-line cell is duplicated before meiosis begins during the S phase.
It will be remembered that I classified replicators into germ-line replicators and dead-end replicators.
In the case of germ-line enhancements, the potential gains are enormous.
RS What do you, personally, see as the main ethical issues surrounding germ-line gene therapy?
In diploid organisms, germ-line cells have two copies of each chromosome.
DC What is at issue when we talk about germ-line editing?
In contrast with somatic mutations, germ-line mutations are passed on to an organism 's progeny.
Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans.
Some founders are germ-line founders.
The risks of germ-line therapy ( widely banned with respect to human applications ) were noted earlier.
It is a smaller unit which I call the active, germ-line replicator.
Often, both functional cassettes are germ-line in sequence or have sequences close to germ-line.
Lander says the Broad Institute is “ uneasy ” with germ-line therapy.
O processes for modifying the germ-line genetic identity of human beings ;.
Germ-line mutation, just as I thought. This man has the exact same disorder.
Figure 25 provides a summary of the germ-line transmitting, targetable rat embryonic stem cell lines.
Germ-line transformation of Arabidopsis.
Does every person with a germ-line c-kit or PDGFRA mutation develop GIST?
Germ-line mutation, just as I thought.
The nucleotide sequences of PCR primers, the Ce germ-line and B-actin transcripts were as follows,.
There are 51 germ-line VH genes in humans and each of these can be recombined.
Male chimeric offspring were mated with C57BL/6 females for germ-line transmission of the δT mutation.
Antibody name, germ-line designation, and sequence ID are indicated for each sequence.
Figure 8 shows the binding curves of 2G7 germ-line revertant humanized antibodies to TGF-beta.
O Germ-line genetic alteration.
