Examples of 'germline sequence' in a sentence
Meaning of "germline sequence"
germline sequence: A term used in genetics to describe the genetic sequence (DNA) that is passed down from generation to generation and is present in every cell of an individual's body
How to use "germline sequence" in a sentence
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germline sequence
Selecting a germline sequence can be performed in different ways.
Dots indicate identity to the human germline sequence.
Acceptor germline sequence is the one with the highest total score.
The exchange cassette may be a human germline sequence.
This germline sequence has not been found as rearranged mature antibody light chain.
Only the differences are printed for the germline sequence.
The germline sequence is then used to fill in missing portions of the variable regions.
At least one of the human exchange cassettes can be a human germline sequence.
The germline sequence is then used to fill in missing portions of the variable region.
In some instances the heavy chain framework sequence is the germline sequence.
The germline sequence of each of the J segments if shown.
This approach is based on the search for the closest human germline sequence.
This germline sequence has been found in a rearranged mature antibody gene with 4 amino acid changes.
The sequences of each clone were compared to the germline sequence of the unrearranged transgene.
One approach is to " backmutate " one or more framework residues to the corresponding germline sequence.
See also
In another embodiment, the light chain germline sequence is a Vkappa or Vlambda sequence.
In some embodiments, the exchange cassette is a human germline sequence.
These positions can be backmutated to the germline sequence by making the following substitution, S?
In a specific case, the single human light chain comprises a germline sequence.
In a preferred embodiment, the human germline sequence is derived from the VK1 6 germline sequence.
The library of claim 1, wherein the exchange cassette is a human germline sequence.
This position can be backmutated to the germline sequence by making the following substitution, N28S.
The first and / or the second exchange cassette may be a human germline sequence.
In some embodiments, the corresponding human germline sequence for the light chain J-segment is Jk2.
The human λ light chain locus may be a substantially full-length germline sequence.
Table 11 lists the germline sequence of FR4 of the heavy chain.
In some embodiments, the first and / or the second exchange cassette is a human germline sequence.
The closest human germline sequence was DP53.
In a more preferred embodiment, the nucleic acid encoding the light chain is the germline sequence.
Most preferably, the A20 VI germline sequence is amplified.
The anti-VIP VI domain contains 4 amino acid replacements compared to its germline sequence.
In certain embodiments, the A20 VI germline sequence is amplified.
Also preferred is V2I modification, which corresponds to modification to a germline sequence for FR1.
Only 12 mismatches were found between the H4 germline sequence and the BAT-1 Vk region.
CDR = complementarity determining region ; FR = framework region ; gin seq = germline sequence.
Sequence analysis of the ELISA-positive HCAb derived from the 3-23 VH germline sequence.
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