Examples of 'glucagon receptor' in a sentence
Meaning of "glucagon receptor"
glucagon receptor: This term refers to a protein molecule on the surface of cells that binds with the hormone glucagon. It plays a crucial role in regulating glucose levels in the bloodstream and is the target of certain diabetes medications
How to use "glucagon receptor" in a sentence
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glucagon receptor
Biphenyl derivatives useful as glucagon receptor antagonists.
Only the glucagon receptor was upregulated in the muscle.
Compositions and methods relating to glucagon receptor antibodies.
The cynomolgus glucagon receptor sequences are identified herein and are presented below.
Novel antagonists of the glucagon receptor.
The glucagon receptor agonists of the present invention seek to meet these needs.
They were evaluated and found to be potent human glucagon receptor antagonists.
Certain glucagon receptor agonists of the present invention are generally effective over a wide dosage range.
Mice with a homozygous deletion of the glucagon receptor exhibit increased glucose tolerance.
Compounds provided herein have been shown to have high affinity for the glucagon receptor.
In one embodiment, the glucagon receptor is expressed by a cell.
The polynucleotide and polypeptide sequences for several species of glucagon receptor are known.
A glucagon receptor agonist compound consisting of the formula,.
The present invention provides compounds that are useful as glucagon receptor antagonists or inverse agonists.
A glucagon receptor agonist compound comprising the formula,.
See also
The compounds in the above table display nanomolar affinity for the human glucagon receptor.
Antagonists of the glucagon receptor inhibit glucagon-induced cAMP production.
Picolinamido - propanoic acid derivatives useful as glucagon receptor antagonists.
Also, inhibition of glucagon receptor expression using antisense oligonucleotides ameliorates diabetic syndrome in db / db mice.
Accordingly, such techniques are useful in preparing antibodies to human glucagon receptor.
Glucagon receptor antagonist compounds, compositions containing such compounds and their pharmaceutical use.
More particularly, these compounds are selective antagonists or inverse agonists of the glucagon receptor.
Table 4 provides glucagon receptor affinity and antagonist activity for several specific glucagon analog antagonists.
Preferably, the oligomers comprise antigen binding proteins that have glucagon receptor binding activity.
Glucagon receptor activation promotes protein kinase A-dependent phosphorylation of phosphorylase kinase.
Without being bound to any particular theory, such glucagon analogs exhibit a reduced glucagon receptor activity.
Analogs of OXM having dual glucagon receptor and GLP-1 receptor activity have been described.
A number of publications have appeared which disclose non-peptide compounds which act at the glucagon receptor.
Another embodiment of the present invention provides a glucagon receptor agonist consisting of Formula I,.
Glucagon receptor antagonists ;.
In certain embodiments, the GCGR is a human glucagon receptor.
Glucagon receptor agonists ;.
Provided herein are peptides which bind both to a glucagon receptor and to a GLP-1 receptor.
A glucagon receptor antagonist;.
Accordingly, an embodiment of the present invention provides a glucagon receptor agonist comprising Formula I,.
The glucagon receptor ( GCGR ), a glucagon hormone involved in glucose regulation.
In animals fasting 24 hrs, a significant increase in glucagon receptor density was also reported.
Glucagon binds to the glucagon receptor, a G protein-coupled receptor, located in the plasma membrane.
Glucagon is produced by the pancreas and interacts with the glucagon receptor ( " glucR " ).
PEPTIDE SYNTHESIS Example 1 Example 1 is a glucagon receptor agonist represented by the following description,.
GLP-1 on the other hand is not capable of activating the glucagon receptor.
Anti-inflammatory agents ; glucagon receptor antagonists ;.
The glucagon receptor agonist of any one of Claims 1-4, for use in therapy.
The cDNA coding for the human glucagon receptor was cloned into expression vector pcDNA3.1 ( Invitrogene ).
The glucagon receptor ( GLUR ) is a G-protein coupled 7-transmembrane domain receptor ( GPCR ) of the secretin family.
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They will give you a shot of glucagon
All the glucagon we have in the fridge
Examples of using Receptor
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Receptor is not sensitive to the type of change
Is that why that receptor network existed
This receptor can exist in three conformations
