Examples of 'glycoforms' in a sentence
Meaning of "glycoforms"
glycoforms (noun) - Different molecular forms of a protein or other molecule that differ in their carbohydrate components
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- plural of glycoform
How to use "glycoforms" in a sentence
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glycoforms
The proposed compositions of the major glycoforms are indicated.
Certain specific glycoforms confer potentially advantageous biological properties.
Effector functions can also be modulated by specific glycoforms.
The generation of different glycoforms of peptides in cells is described above.
Plasminogen exists in two glycoforms.
A lectin assay for assessing glycoforms as an early marker in disease.
There are however differences in glycoforms.
All glycoforms eluting at the same retention time were considered together.
This results in microheterogeneity and the formation of a complex family of glycoforms.
The engineered glycoforms can be attached at any amino acid of the variant sequence.
Peaks with greater masses correspond to the presence of various glycoforms.
Thus the glycoproteins will include glycoforms that are not seen in chicken eggs.
Glycofi has also developed yeast cell lines capable of producing specific glycoforms of antibodies.
Thus the HA may include glycoforms that are not seen in chicken eggs.
The present invention contemplates antibodies that comprise modified glycoforms or engineered glycoforms.
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The glycoforms produced by the engineered CHO cells were considered to have optimized ADCC.
Synergy of Fc variants and engineered glycoforms.
All these glycoforms were assessed in the 6 formats defined above.
Described herein are Fc variants that comprise modified glycoforms or engineered glycoforms.
Re-engineering glycoforms of immunoglobulins expressed by mammalian cells is a tedious and cumbersome task.
Useful HA includes canine glycoforms.
Once separated, the glycoforms can be recombined to generate the desired ratio.
These data help explain the functional differences between the type I and type II plasminogen glycoforms.
Specific sCR1 glycoforms may also be selected vÃa lectin affinity chromatography or chromatofocusing.
Interferons are known to be glycosylated, often with different glycoforms.
However, altered glycoforms are often associated with disease states such as cancer.
Our cells are covered with fibers, which are called glycoforms.
Depending upon the glycoprotein, different glycoforms can yield different functional profiles.
Similarly, a mutant was generated which permitted investigation of sialylated glycoforms.
In this way, glycoforms are initially characterized with reducing and non-reducing polyacrylamide gels.
Antibodies, in common with most glycoproteins, are typically produced as a mixture of glycoforms.
Hence, certain glycoforms that modulate desired antibody activities can confer therapeutic advantage.
In this manner, different patterns of glycan attachment yield different glycoforms of a glycoprotein.
In certain embodiments, the glycoforms may be isolated by reverse phase HPLC.
Using such methods, it is possible to attain maximally-sialylated glycoforms of antibody samples.
In the present example, a-Gal A glycoforms were fractionated by size and by charge.
Antibodies, in common with most glycoproteins, are typically produced in nature as a mixture of glycoforms.
Such glycofomrs notably encompass oversialylated or resialylated glycoforms of recTSH and / or defucosylated glycoforms of recTSH.
The invention also provides methods of producing, detecting, and purifying such glycoforms.
These eight essential sugars supply the body with glycoforms that are needed for cell-to-cell communication.
N-linked sialic acid was calculated based on the fractions of asialylated and sialylated glycoforms.
In a preferred embodiment, the said glycoforms are attached at amino acids of the Fc region.
In the disease state, however, this structure is only one of numerous glycoforms observed.
In addition, the invention utilizes engineered glycoforms that can enhance Fc / FcYR affinity and effector function.
The benzamidine-coupled affinity column exhibits differential binding affinity to the two glycoforms.
Useful HA includes canine glycoforms e.g. the virus may have been grown in MDCK cells.
Thus, fractionation tools are necessary to isolate efficiently changed protein glycoforms on the blood proteome.
One or more glycoforms are present in a recombinant anti-CD19 antibody population.
The present inventors have applied various purification methods to resolve and enrich particular sCR1 glycoforms.
Glycoforms of such antibodies include those with a glycan moiety at position 297.
