Examples of 'gtpase' in a sentence
Meaning of "gtpase"
GTPase is a noun that refers to a protein that acts as a molecular switch, playing a role in signal transduction pathways
How to use "gtpase" in a sentence
Basic
Advanced
gtpase
The endogenous GTPase activity of mutations is reduced.
One well known member of this class is GTPase.
A method of activating a GTPase is furthermore provided.
The GTPase is normally inactive.
The other is covalently modifying the GTPase itself.
A method of activating a GTPase is furthermore provided by the invention.
A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane.
A method of activating a small GTPase is furthermore provided by the disclosure.
The localization of GEFs can determine where in the cell a particular GTPase will be active.
Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell.
Cycling from active to inactive is accomplished by the intrinsic GTPase activity of the protein.
Impaired GTPase activity in a regulatory protein also can lead to cancer.
It stimulates the GTPase activity of Ras.
GTPase activity may be measured by methods common in the art.
These mutated forms have less GTPase activity so they remain in an active state.
See also
Acceleration of GTP hydrolysis by GAPs reduces the amount of active GTPase.
Analysis of a putative Rab GTPase activating protein in endocytic trafficking.
KRAS encodes a protein that is a member of the small GTPase superfamily.
KRAS is a GTPase with a role in a number of signal transduction pathways.
Binding of this protein inhibits the GTPase activity of Rho proteins.
GTPase HRas is involved in regulating cell division in response to growth factor stimulation.
Cytosollocalized forms of Ras with normal GTPase activity do not act as inhibitors.
Ligand binding induces a conformational change that allows the GPCR to activate an associated GTPase.
The Ras proteins are small GTPase enzymes that transmit signals within cells.
Genetic studies in Drosophila have shown the importance of activating the small GTPase Rac.
Cytosol localized forms of Ras with normal GTPase activity do not act as inhibitors.
These guanine nucleotide exchange factors interact with and activate the GTPase Ras.
GDP remains bound to the inactive GTPase until a GEF binds and stimulates its release.
The search for proteins responsible for metastasis has implicated Ras homology gene family GTPase RhoC.
RAS small GTPase signalling to the enigmatic RASSF death effectors.
The alpha subunit of G proteins is a weak GTPase.
RhoU GTPase which has potential functions in JNK signalling and cytoskeleton dynamic.
In exemplary aspects, the small GTPase of the method of the invention is RhoA.
It is responsible for the regulation of Arf1p GTPase.
G proteins comprise a GTPase which hydrolyses GTP to form GDP and inactivates the G protein.
However, the most differentially expressed gene of the four was RAN GTPase.
The amount of active GTPase can be modified in several ways,.
This family consists of the G protein alpha subunit, which acts as a weak GTPase.
Mutants defective in GTPase activity often still divide, but sometimes form twisted and disordered septa.
These proteins are GTP ( guanine nucleotide triphosphate ) binding proteins with intrinsic GTPase activity.
RAC1 is a GTPase also activated by insulin.
The NF1 gene is inactivated, which activates the GTPase activity of the ras oncogene.
Rho, Rab, and Arf GTPase families are involved in actin cytoskeleton dynamics and vesicular trafficking.
Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity.
Abstract, Ras subfamily of small GTPase proteins holds a key position in cell proliferation pathways.
The NRAS protein is a GTP / GDP-binding protein having an intrinsic GTPase activity.
NRAS functions as an oncogene with GTPase activity and can be found on chromosome 1p.
GTPase activity is therefore a measure of G protein and therefore CCRL2 activity.
The OPA1 gene codes for a dynamin-related GTPase protein targeted to the mitochondrial inner membrane.
The function of atlastin-1 is crucially dependent on its GTPase activity.
