Examples of 'heparinase' in a sentence
Meaning of "heparinase"
heparinase (noun) - an enzyme that catalyzes the hydrolysis of heparin, used in medical and research contexts
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- Any enzyme that catalyses the hydrolytic cleavage of heparins
How to use "heparinase" in a sentence
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heparinase
Depolymerizing heparin by digestion with an heparinase.
In vivo heparinase treatment would result in decreased inflammatory responses.
They inhibit the activity of enzymes such as heparitinase or heparinase.
A further purification of the heparinase was achieved by hydroxylapatite column chromatography.
Preparation of the heparinase.
The heparinase fraction recovered is free of the contaminating anticoagulant moiety.
Biodegradable synthetic polymers are particularly useful to effect the controlled release of heparinase.
The heparinase may be immobilized by any method known in the art.
An accelerated heparin clearance was noted as compared to rabbits which did not receive heparinase.
The heparinase is gradually added in the reaction mixture until hydrolysis is over.
The circles indicate the levels in heparinase treated rats which underwent ischemia.
Several compounds have been examined for their ability to stabilize a soluble heparinase preparation.
Appropriate administration of heparinase could extend the duration of diminished inflammatory response.
Langer was able to achieve better reversal by pumping blood through an immobilized heparinase reactor.
The modified heparinase may have a reduced enzymatic activity with respect to HLGAGs.
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These data indicate the utility of compositions containing heparinase for diminishing localized inflammatory responses.
The heparinase is also useful for the in vivo neutralization of heparin during surgical procedures.
The invention arose from several scientific findings which expand the field of heparinase biology.
Heparinase III plasma levels were determined as described in example.
The invention further provides functional derivatives of the sequences of heparinase II.
Heparinase activities were determined by the spectrophotometric assay described by Yang et al.
The invention further provides functional derivatives of the sequences of heparinase III.
The modified heparinase III of the invention is useful as such a tool.
The present invention provides a series of new modified heparinase III molecules.
Heparinase III is an enzyme that cleaves sugar chains at glucuronidic linkages.
It may be that these histidines are necessary for proper folding of heparinase III.
Heparinase III also contains no cysteines in its amino acid sequence.
These fragments can be generated by modified heparinase III treatment of cancer cells.
The modified heparinase III compounds may also be linked to a targeting molecule.
Nucleic acid sequences and expression systems for heparinase II derived from flavobacterium heparinum.
The heparinase may be overexpressed from a recombinant nucleotide sequence in Flavobacterium heparinum or Escherichia coli.
This modification produces a modified heparinase II which becomes exclusively a heparan sulfate degrading enzyme.
This analysis confirmed that these inserts were part of the gene encoding heparinase III.
Heparinase I digestions were designated either short or exhaustive.
The time course of inactivation for both was determined using the heparinase III activity assay.
Heparinase III and uses thereof.
The Rhomberg study utilizes heparinase to degrade HLGAGs to produce HLGAG oligosaccharides.
Heparinase 3 was added to the vehicle as described above.
The authors noted the requirement for purifying the heparinase from crude extracts of F.
The heparinase may be heparinase III.
Natural selection against clones containing the entire heparinase II and III genes was observed.
Plasma levels of heparinase III are measured using a heparinase III ELISA.
Other names in common use include heparin eliminase, and heparinase.
Preparation of Pharmaceutical Compositions Heparinase enzyme is administered locally.
The levels of heparinase 1 activity in the supernatants were similar.
However, means for supplementing with liquid heparinase is also shown.
The highly purified heparinase previously obtained was added to the solution as follows,.
In another aspect, the invention is an immobilized substantially pure heparinase of the invention.
The effect of the human heparinase treatments on neutrophil extravasation are shown in figure 9.
A-Depolymerizing heparin by digestion with an heparinase.
