Examples of 'heregulin' in a sentence
Meaning of "heregulin"
'Heregulin' as a noun refers to a specific protein that plays a role in cell growth and differentiation
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- Synonym of neuregulin
How to use "heregulin" in a sentence
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heregulin
The heregulin variant may be a variant of a mammalian heregulin.
The cells are cultured in the presence of an effective amount of a heregulin variant.
The biological role of heregulin has been investigated by several groups.
Other aspects of the invention relate to various uses of a heregulin variant.
A pharmaceutical heregulin variant composition may be employed to treat a mammal.
The inhibiting antibody may be added in the presence of ligand such as heregulin.
A heregulin variant can also be employed to improve neural function.
Their findings also indicated that heregulin functions in the development of epithelia.
A heregulin variant according to the invention is capable of binding an ErbB receptor.
The resulting cells are then screened for high levels of heregulin variant production.
Various heregulin polypeptides encompassed by this term have been disclosed above.
This indicated another cellular component was necessary for conferring full heregulin responsiveness.
A heregulin variant composition intended for in vivo administration is typically sterile.
Selective binding between biotin and avidin links the label to the heregulin variant.
A pharmaceutical heregulin variant composition can be administered continuously by infusion or by bolus injection.
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This finding indicated that another cellular component was necessary for conferring full heregulin responsiveness.
The heregulin variant can also be expressed intracellularly and recovered from cell lysates.
Such phosphorylation of Axl and Rse is not observed in cultures stimulated with heregulin.
The administration of a heregulin variant of the invention can be combined with other therapeutic regimens.
In one embodiment the ability of the ADC candidate to block heregulin binding is evaluated.
A heregulin variant of the invention can replace the other heregulin polypeptides used in these methods.
Preliminary studies were performed using Heregulin and FGF.
Heregulin Variants The present invention includes a heregulin variant.
In some embodiments, the biomarkers include heregulin.
Generally, chimeric heregulin variants are produced by recombinant techniques.
A synergistic effect is also observed between gas6 and heregulin.
For example, the invention provides a heregulin variant that is a fragment.
Accordingly, the invention encompasses a pharmaceutical composition including a heregulin variant.
In a variation of this embodiment, the heregulin variant may be a variant of a human heregulin.
These researchers also showed that ErbB-2 is a critical mediator of heregulin responsiveness.
A sustained-release heregulin variant preparation may include a liposomally entrapped heregulin variant.
Alternatively, the label can be bound to the heregulin variant indirectly.
Furthermore, a heregulin variant of the invention can be used to treat neuropathy, especially peripheral neuropathy.
The label can be conjugated directly to the heregulin variant, as described above.
The polypeptide of claim 8, wherein the polypeptide further comprises a targeting domain of heregulin.
The heregulin variants of the invention are useful in a variety of therapeutic and non-therapeutic applications.
If desired, a sustained-release preparation can also be used to administer a heregulin variant.
A heregulin variant is produced by any suitable method, including peptide synthesis and recombinant techniques.
For instance, the mammal may be administered a combination of both heregulin and betacellulin.
For example, the heregulin variant can also have the ability to activate an ErbB receptor.
The best sequence alignment for a number of heregulin polypeptides is shown in Figure 1.
A heregulin variant of the invention is capable of binding ErbB-3 receptor.
All conditions received low Activin and Heregulin at stage 4.
The term " heregulin variant " means a polypeptide variant of a native heregulin.
Basal levels of phosphorylated AKT-2 were unaffected by treatment with Heregulin or Herceptin.
These isolated NDF, ARIA and GGF heregulin polypeptides are well known in the art.
In still one more aspect, Active A is added alone or combined with Heregulin at stage 4.
Genotypic groups receiving the heregulin consisted of 6 females and 6 males each.
Activin A may be added alone or combined with Heregulin at stage 4.
However, heregulin has been shown to induce phosphorylation by activating Her2.
