Examples of 'herg' in a sentence
Meaning of "herg"
herg (noun) - This phrase does not have a commonly known definition in English language
How to use "herg" in a sentence
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herg
Lubication pump herg japan joint venture.
Have returned from a visit to herg.
This opens hERG channels and permits efflux of rubidium.
All compounds seemed to have no or only little effect on hERG.
In vitro hERG potency and in vitro protein binding of rifaximin.
This complicated voltage protocol is standard for recording hERG currents.
Expression of hERG current can vary depending on cell culture conditions.
Preferred compounds of the present invention have low hERG activity.
The measurement of the hERG current was performed in the following two steps.
A positive control confirmed the sensitivity of the test system to hERG inhibition.
Arrhythmia can be induced by a blockage of hERG channels by a diverse group of drugs.
This was repeated three times and an average thereof was taken as hERG current.
Interaction with the hERG channel is one indicator of potential cardiac toxicity.
Composition of internal and external solutions used in hERG patch clamp studies.
Research will explore how hERG is acting at a molecular level to have this effect.
See also
Some commonly consumed botanical products contain compounds known as hERG channel blockers.
One method for measurement of hERG activity is the patch clamp electrophysiology method.
The compounds of the present invention exhibit a desirably low activity against hERG.
Interaction with with the hERG channel is one indicator of potential cardaic toxicity.
Also shown is the voltage pulse protocol used to evoke the hERG currents.
Preclinical hERG studies should be accomplished in GLP environment.
Other in vitro selection criteria for loxapine analogs of the invention includes hERG binding.
CHO cells expressing hERG in a stable manner are used for these studies.
Potential for QT prolongation was assessed in the hERG patch clamp assay.
Does hERG coassemble with a beta subunit?
Compounds of formula I have favorable hERG channel inhibition properties.
LKr Potassium ion channel whose activity is measured in the hERG assay.
Cardiovascular safety, hERG and patch clamp.
Thus, hERG binding has been becoming a major hurdle in current drug development.
Furthermore, it does not inhibit the hERG channel activity.
Quinidine, an established hERG inhibitor, was included as an experimental control.
Compounds were tested in either of the following assays, hERG binding assay.
Crofelemer inhibited hERG tail current in a dose-dependent manner.
Maraviroc preserved excellent antiviral activity, whilst demonstrating no significant hERG binding affinity.
For studies of hERG or LKr ion channels, the following information should be provided,.
Furthermore, compounds of the present disclosure may have a surprisingly advantageous hERG profile.
The hERG currents increased slightly, but became stable after the second wash.
Iloperidone has a high affinity to the hERG channels and causes QTc exposure-dependent prolongation.
The hERG inhibition of selected compounds in this patch clamp assay is listed in Table 13.
Lamotrigine caused a dose-related inhibition of the hERG channel tail current in human embryonic kidney cells.
A smaller IC50 in this dofetilide assay means a greater probability of potent hERG blockade.
For binding to hERG, HEK cells stably expressing hERG were used.
KCNE2 was originally discovered to regulate hERG channel function.
It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval.
Furthermore, the compounds of the invention are selective against the hERG K+ channel.
The hERG channel is heterologously expressed in a CHO ( Chinese Hamster Ovary ) cell line.
The preferred compounds of formula ( I ) have low hERG ion channel blocking activity.
The compound of formula ( I ) is potentially less toxic than prior art compounds . hERG.
Results of hERG are given in Table 7.
This was followed by a hyperpolarising step of 1s to 30mV to evoke the hERG tail current.
