Examples of 'heterodimerization' in a sentence
Meaning of "heterodimerization"
'Heterodimerization' is a noun used in biochemistry to describe the process by which two different molecules come together to form a dimer
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- The formation of a heterodimer.
How to use "heterodimerization" in a sentence
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heterodimerization
Such mutations favor heterodimerization over homodimerization.
Heterodimerization with ERRalpha inhibited the transcriptional activity of ERRgamma.
The dimerization sequence may be a heterodimerization sequence.
Again the heterodimerization of the desired bispecific molecule was very selective.
This class of molecules is created by heterodimerization of two constituting components.
Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism.
These alterations facilitate heterodimerization and disfavor homodimerization.
Mispaired side products are avoided due to use of asymmetric heterodimerization strategies.
The first and second heterodimerization domains may be leucine zippers.
The method according to claim 5, wherein the measured interaction is a heterodimerization.
These differences facilitate heterodimerization and reduce homodimerization.
In this embodiment, electrostatics are used to skew the formation towards heterodimerization.
A multi switch can comprise heterodimerization switch domains or homodimerization switch domains.
Alternatively, the engineering is such that homodimerization is favored over heterodimerization.
Strategies based on forcing the heterodimerization of two heavy chains have been explored.
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In some embodiments, the human IgG constant region is modified to induce heterodimerization.
A classic example of heterodimerization is provided by the heavy and light chains of an antibody.
These can be optionally and independently combined with other heterodimerization variants of the invention.
Suggest that heterodimerization of PRLR can positively or negatively activate PRI transcription.
The goal during this step is to prevent heterodimerization of barcoded product.
Recently, various heterodimerization techniques have been used to improve the production of bispecific antibodies.
With some receptor kinases, receptor heterodimerization can also occur.
PPARδ has protein heterodimerization activity and retinoid X receptor binding activity.
The enzymatic activity of receptor tyrosine kinases can be stimulated by ligand-mediated homodimerization or heterodimerization.
May also promote the heterodimerization with the EGF receptor.
Black dot, optional modification in the Fc domain promoting heterodimerization.
As discussed below, heterodimerization variants can include steric variants e . g.
Once recruited, STAT proteins are phosphorylated by which induces their homo - or heterodimerization.
In addition to the heterodimerization variants e . g.
This heterodimerization then activates the 5 ' regulatory region of the target expression cassette.
Panel E depicts an immunoconjugate in which dimerization is achieved vÃa a CH1/Ckappa heterodimerization interaction.
Construction, expression, and heterodimerization properties of SEED molecules with reduced immunogenicity.
Most of them are monomeric proteins, although GABAB receptors require heterodimerization to function properly.
The heterodimerization domains may be derived from Human Pancreatic RNases and S-peptide.
Figure 2B depicts a bispecific IgG, again with the option of a variety of heterodimerization variants.
The heterodimerization domains may be derived from the Bacterial Ribonuclease ( Barnase ) and Barnstar peptides.
Specific engineering in the CH3 domains was applied in order to favour heterodimerization over homodimerization.
These heterodimerization extensions, however, might be immunogenic.
Figure 6, Diagram of disruption of dimeric AraC hybrids through heterodimerization with LexA hybrids.
Preferably, this heterodimerization domain is a " leucine zipper " domain.
The CH3 domains of the Fab arms may be engineered to favor heterodimerization over homodimerization.
Preferential heterodimerization of EGFR and Neu receptor Qian et al ., Proc.
The VHCH1-VLCL interaction is proposed as a very efficient heterodimerization scaffold that could be efficiently produced.
Preferably the HER dimerization inhibitor is a HER2 dimerization inhibitor and / or inhibits HER heterodimerization.
Figure 38 depicts the remarkable " skew " towards heterodimerization using variants of the invention.
Heterodimerization of the IL-2 receptor B - and Y-chain cytoplasmic domains is required for signalling.
Notably, ErbB3 is kinase-impaired and requires heterodimerization for activation.
For example, heterodimerization domains may interact to form multimers ( e.g. trimers or tetramers ).
ER-B in some cases functions as an antagonist of ER-a through heterodimerization with ER-a.
Figures 4A, 4B and 4C depicts a subset of heterodimerization variants of Figure 3 finding particular use in the invention.
