Examples of 'high affinity binding' in a sentence
Meaning of "high affinity binding"
High affinity binding: In biochemistry, high affinity binding refers to a strong and specific interaction between two molecules. This term is commonly used to describe the tight bonding between a ligand and its receptor
How to use "high affinity binding" in a sentence
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high affinity binding
A single high affinity binding component was identified.
The nM km value suggests comparatively high affinity binding.
The high affinity binding site is the value shown above.
It is surmised that specific bases are necessary to support this high affinity binding.
High affinity binding is thought to result from the clustering of multiple CRDs.
Phage panning of such libraries can isolate high affinity binding antibodies.
Relatively high affinity binding sites for steroids have been identified on nuclear envelopes.
Resistance to protease degradation also correlates with high affinity binding to target ligands.
This yields high affinity binding that is desirable according to the present invention.
This antibody requires the amino terminal tyrosine for high affinity binding.
It may also be a high affinity binding member such as a molecule with a higher affinity constant.
Occupancy of the ion binding site is required for high affinity binding of the antigen.
High affinity binding molecules amenable to chemical synthesis may provide a valuable alternative to antibody technology.
Antigen and antibody interact through a high affinity binding much like lock and key.
A high affinity binding reagent will have a higher analyte sensitivity than a lower affinity binding reagent.
See also
The cholesterol modifed aptamer retained high affinity binding to FIXa Fig.
High affinity binding site of HGFR and methods for identification of antagonists thereof.
Amplification of the EPOR copy number increased the low affinity but not high affinity binding.
The high affinity binding to the GHSR makes up yet another aspect of this invention.
Example 9 describes the minimal sequence necessary for high affinity binding.
This high affinity binding domain is preferably directed at a Benefit Agent.
Thus, there is no need to select for high affinity binding activities in a single step.
High affinity binding to target kallikreins to minimize dose ;.
Thus, in some preferred aspects of the disclosure, high affinity binding epitopes are used.
High affinity binding to target enzymes to minimize dose ;.
Clearly, untethering can increase the proportion of receptors available for high affinity binding.
All three three-finger domains are necessary for high affinity binding of the primary ligand, urokinase.
The binding site of antibodies typically utilizes multiple non-covalent interactions to achieve high affinity binding.
This tyrosine provides a high affinity binding site for a src SH2 domain.
Preferably, the VEGF receptor molecule is characterised by high affinity binding to VEGF.
Specific and high affinity binding to GRPr-expressing cells was demonstrated by Scatchard analysis.
More preferably the binding to FGFR3 is a high affinity binding with no biological activity.
Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase.
This comes at a reduced selectivity, since it displays also high affinity binding to human CEACAM5.
This antibody displayed high affinity binding to both human and monkey CEACAM6.
The substitution pattern indicated in Figure 9 is compatible with high affinity binding to PDGF-AB.
Receptor analyses demonstrated high affinity binding sites for IGF-I on membranes of both tumors.
Antibody binding to beta-amyloid plaques with concentrations of 50 pM suggest high affinity binding.
In Sortilin, the propeptide exhibits high affinity binding to the fully processed receptor.
Probably, high affinity binding does not essentially require di -, tri - or tetraantennarity of the glycoside.
Preferably the binding to FGFR3 is a high affinity binding with reduced biological activity.
These high affinity binding sites were absent in the cells expressing gp130 alone.
The presence of the two chains is required for high affinity binding of Type 1-IFN.
These properties include high affinity binding to human PTK7 and binding to Wilms ' tumor cells.
Interestingly, at this position, aliphatic ( rather than aromatic ) residues were associated with high affinity binding.
Site 1 is a high affinity binding site and site 2 a low affinity site.
Titration of DC-SIGN-Fc to PMN reveals high affinity binding of DC-SIGN to PMN.
A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor " . Eur.
These properties include high affinity binding to human Glypican-3.
High affinity binding of 9A6 to human CEACAM6 was confirmed.
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