Examples of 'high-affinity' in a sentence
Meaning of "high-affinity"
High-affinity: describing a strong or tight bond between molecules or the preference for a particular target with great specificity
How to use "high-affinity" in a sentence
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high-affinity
Engineered high-affinity human t cell receptors.
Albumins have been found to contain a high-affinity zinc binding site.
It is a high-affinity choline uptake enhancer.
The curves can also be used to identify high-affinity compounds.
The own brand high-affinity theatre is terrified.
Two hybridoma supernatants showed the presence of high-affinity antibodies.
In this high-affinity fragment eight sulfate groups are present.
This approach could be applied to other high-affinity pKA inhibitors.
Selective high-affinity polydentate ligands and methods of making such.
This approach could be applied to other high-affinity plasmin inhibitors.
High-affinity binding was indeed evident involving four of the candidate molecules.
There is only a single high-affinity metalloid binding site in ArsA.
These cell products are captured and detected using high-affinity antibodies.
Under specific conditions, high-affinity phosphate transporter synthesis can be increased.
In certain embodiments, a short antisense oligonucleotide has at least one high-affinity modification.
See also
In certain embodiments, the high-affinity modified nucleotides are sugar modified nucleotides.
Dislosed herein are anti-alpha toxin antibodies and fragments that are a high-affinity antibody.
At low substrate, the high-affinity site is occupied and normal kinetics are followed.
Most of the later group of receptors exists in high-affinity form as a heterodimers.
These can produce high-affinity IgE which is the essence of allergic diseases.
This interaction maintains the androgen receptor in a high-affinity ligand binding conformation.
Two classes of these high-affinity binding reagents are currently used, aptamers and tadpoles.
In certain embodiments, short antisense compounds comprise at least one high-affinity modified monomer.
Immunophilins are an example of high-affinity and specific binding proteins having physiological significance.
Successive mutation and selection / screening steps are then needed to generate high-affinity antibodies.
In particular, bacteria have evolved very high-affinity sequestering agents called siderophores.
These high-affinity receptors are located both synaptically and extrasynaptically on the granule cell.
A process according to claim 9 wherein the high-affinity ligand is a pharmaceutically active moiety.
Secondly, high-affinity monoclonal antibodies and the genes coding for them are obtained.
Compositions and methods for delivery of high-affinity oxygen binding agents to tumors.
High-affinity specific androgen and estrogen receptors are present in the cytosol and nuclear fractions.
This analysis identified the existence of high-affinity androgen receptors within these cells.
Moreover, high-affinity compounds can be generated without the need to proceed via an immunization step.
The receptor seems to depend on the lipid environment for high-affinity binding capability.
Once they found high-affinity peptide binders, they tested them in biological assays.
The linker is capable of forming covalent bonds or high-affinity non-covalent bonds to both molecules.
Any of several known high-affinity interactions can be adapted to, noncovalently connect the two moieties.
The retained agarose contains any residual enzyme bound vía the high-affinity avidin-biotin interaction.
The identification of the high-affinity pentasaccharide fragment inspired the preparation of synthetic analogues thereof.
Antibodies produced using the afore-mentioned procedures were subsequently tested for high-affinity binding as follows.
The high-affinity scFv also bound indium and gallium chelates with nanomolar affinity.
In all cases, the product is a combination of the high-affinity antibody and human antibody sequences.
Eventually, suitably high-affinity peptides are identified and then screened for biocompatibility and target specificity.
The efficient targeting of uPAR demands a selective high-affinity vector that is chemically robust and stable.
NPAR is a high-affinity thrombin receptor present on the surface of most cells.
We conclude that mononuclear cells have specific high-affinity binding sites for vasoactive intestinal peptide.
QCM measurements indicated the contribution of avidity effects to high-affinity binding.
Such interactions are highly specific, and the high-affinity complexes are formed with extremely rapid kinetics.
Adenylyl cyclase activity was inhibited at concentrations of PGE2 that occupy the high-affinity receptor.
Specificity of the high-affinity glucose transport system of Pseudomonas aeruginosa was examined.
