Examples of 'hirudin' in a sentence
Meaning of "hirudin"
hirudin (noun) - a naturally occurring peptide in leeches that acts as a blood thinner
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- A peptide, obtained from the salivary glands of leeches, that is used as an anticoagulant.
How to use "hirudin" in a sentence
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hirudin
The hirudin is purified and used as medicine.
This is especially desirable in the case of hirudin.
Hirudin was present during the entire experiments.
In the medium no hirudin activity is detectable.
Hirudin is used for the inhibition of thrombin.
However this does not disprove hirudin as a possible treatment.
Hirudin inhibits thrombin according to a competitive type mechanism.
Bivalirudin is a synthetic polypeptide analogous to hirudin.
All the hirudin activity is found in the supernatant.
The pharmacokinetics of the two variants of hirudin are identical.
Hirudin is a potent natural inhibitor of coagulation.
Their effect is greater than that of unsulfated hirudin.
Peptides of hirudin were tritiated by catalytic reduction.
Maturation at this cleavage site releases an inactive hirudin.
Hirudin was not adsorbed on said gel.
See also
The inhibition of thrombin by mutant hirudin peptides is studied.
These inhibitors qualitatively mimic the action of hirudin.
Lepirudin is a recombinant hirudin that acts as a direct thrombin inhibitor.
Hirudin contains several lysine groups in its peptide sequence.
It also has plenty of hirudin.
Hirudin is a direct inhibitor of thrombin.
Property of the hirudin obtained.
Hirudin and hirulog are two additional thrombin specific anticoagulants.
Preferably the anticoagulant region comprises the sequence of a hirudin.
Hirudin and its derivatives are also obtainable by recombinant techniques.
Pharmaceutical compositions containing hirudin.
The hirudin activity is measured by the thrombin inhibition assay.
Examples of well known thrombin inhibitors are heparin and hirudin.
The activity of hirudin is assayed using a test for thrombin inhibition.
The invention includes the use of hirudin and hirudin variants.
Hirudin inhibits thrombin by binding to the latter at two separate sites.
The anticoagulant properties of hirudin have been known for a long time.
Hirudin inhibited thrombin generation and ultimately led to pain relief.
They are also smaller than hirudin and therefore less antigenic.
Other enzymes of the blood coagulation cascade are not inhibited by hirudin.
Variants of hirudin which can be used as thrombin inhibitor have already been described.
It would be desirable to develop a shortened thrombin inhibitor of the hirudin type.
Hirudin reacts specifically with thrombin and thus prevents blood coagulation.
This test requires injection of hirudin to the subject for testing thrombin.
The hirudin nucleic acid sequence was optimized for plant codon usage.
A freshly thawed sample of labeled hirudin is then used for each experiment.
The endopeptidase activity of yscF is necessary to the maturation of this hirudin precursor.
Naturally occurring hirudin typically contains a mixture of various isoforms of this protein.
Furthermore the compounds of this invention show inhibitory activity comparable to hirudin.
The poor stability can be seen when hirudin is analysed by chromatographic methods.
The depot effect is shown by the longer lasting action of the hirudin.
This study suggests that hirudin can constitute a useful clinical agent as an anticoagulant.
The thrombin and plasmin generation in the presence of different hirudin concentrations was tested.
Hirudin has been the subject of much study in animals for its anticoagulant properties.
Therefore other principles apart from hirudin must be responsible for this effect.
