Examples of 'human dnase' in a sentence
Meaning of "human dnase"
human dnase: Refers to deoxyribonuclease, an enzyme that breaks down DNA molecules in humans. This phrase is commonly used in the context of genetics or biochemistry
How to use "human dnase" in a sentence
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human dnase
Glycosylation variants are included within the scope of human DNase.
Recombinant human DNase.
Examples of human DNase amino acid sequence variants are described in the table below.
The other function is to direct the expression of human DNase II.
The amino acid sequence variants of human DNase are predetermined or are naturally occurring alleles.
Human DNase is defined as a polypeptide having the amino acid sequence of Fig.
There are a variety of ways in which one can make hyperactive variants of human DNase I.
Human DNase II can be formulated according to known methods to prepare therapeutically useful compositions.
The resulting cells then are screened for production of desired amounts of human DNase II.
Recombinant human DNase I was tested as a therapeutic agent.
The present invention is also directed to isolated nucleic acids encoding said human DNase I variants.
DNA encoding a human DNase I variant is inserted into a replicable vector for further cloning or expression.
The inventors created several classes of human DNase I variants.
Additionally, deamidated human DNase may arise upon in vitro storage of non-deamidated human DNase.
The other function is to direct the expression of a human DNase I variant.
See also
Figure 9 shows chromatograms of several human DNase samples fractionated on an immobilized DNA analog column.
Prokaryotic host cells also may be used for expression of DNA encoding human DNase II.
A typical tryptic map of human DNase is shown in Figure 3.
Prokaryotichost cells also may be used for expression of DNA encoding a human DNase I variant.
Figure 7 shows chromatograms of several human DNase samples fractionated on a TCX column.
Prokaryotic host cells also may be used for expression of DNA encoding a human DNase I variant.
Purified deamidated human DNase and purified non-deamidated human DNase were prepared by TCX chromatography.
In one embodiment, the therapeutic is human DNase.
Recombinant human DNase I is another clinically used DNase 1.
At higher pH, the rate of deamidation of human DNase is increased.
Human DNase expressed in E. coli is active.
A process comprising separating deamidated and non-deamidated human DNase from a mixture thereof.
Additionally, human DNase is found naturally with an arginine or a glutamine residue at amino acid 222.
For reported adverse events, no significant differences between recombinant human DNase and placebo were noted.
Accordingly, cDNA for human DNase I was cloned and expressed.
Figure 1 depicts the amino acid and DNA sequence of human DNase.
A plasmid was constructed for recombinant expression of human DNase I as an intracellular protein in E. coli.
In a further embodiment, the therapeutic composition comprises cells actively producing human DNase II.
The relative specific activity of native human DNase I and variants are shown in Figure 2.
There are a variety of ways in which one can make actin-resistant variants of human DNase I.
The relative specific activity of native human DNase I and variants are shown in Figures 2A-D.
In a further embodiment, the therapeutic composition comprises cells actively producing a hyperactive variant of human DNase I.
Preferably, the DNA-digesting protein is human DNase or bacterial endA.
In some embodiments, the DNase domain is an aglycosylated, underglycosylated, or deglycosylated human DNase.
Figure 5 is a chromatogram of a human DNase sample fractionated on a tentacle cation exchange ( TCX ) column.
Tryptic Mapping . The procedure used for tryptic mapping of human DNase is summarized as follows,.
A human DNase 1L3-albumin-RNase hybrid nuclease-albumin molecule may be constructed and expressed.
Figure 2 shows the relative specific activity of native human DNase I and variants.
The sample designated " Non-deamidated standard " refers to purified non-deamidated human DNase.
Figures 2-6 identify the different human DNase I variants that were made.
One unit of enzyme assayed corresponds to 0.6 ng of purified human DNase I.
Figures 2A-D show the relative specific activity of native human DNase I and variants.
The sample designated " Deamidated Standard " is purified deamidated human DNase.
SEQ ID NO, 2 provides the amino acid sequence for human DNase 1.
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