Examples of 'human framework' in a sentence
Meaning of "human framework"
The essential structure or system that outlines the basic characteristics and functions of being human
How to use "human framework" in a sentence
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human framework
The natural framework and the human framework.
It consists essentially of human framework residues and murine hypervariable residues.
Fully human monoclonal antibodies include human framework regions.
The human framework pool is selected for maximum sequence diversity.
Grafting donor CDRs into the recipient human framework.
Human framework to provide an antibody molecule for use in the invention.
A radically human framework.
Improving governance and reinforcing the institutional and human framework.
Mouse framework residues replaced by human framework residues are indicated as sphere models.
Antibodies of the present invention further comprise a human framework region.
The human framework pool is selected to provide maximum framework sequence diversity.
Standard text indicates a change from a human framework residue to mouse.
Human framework regions can be chosen to maximize homology with the mouse sequence.
Those skilled in the art will be aware of a variety of human framework regions.
Numerous human framework sequences have been isolated and their sequences reported in the art.
See also
The other effort was to test different human framework for the humanization.
The properties of a humanized antibody are also affected by the choice of the human framework.
This substitution replaced the human framework residue with the corresponding mouse framework residue.
Additional framework region modifications can be made within the human framework sequences.
Human framework regions most similar to the murine sequence are inserted between the murine CDR.
Humanisation typically involves grafting CDRs identified thereby into human framework regions.
A second approach utilizes a consensus human framework derived from human VI and VH subgroups.
Additional framework region modifications may be made within the human framework sequences.
Preferably, the human framework sequence will not itself be significantly immunogenic.
The framework regions of the variable regions are substituted by corresponding human framework regions.
Physical and Human framework.
These murine amino acid residues are then superimposed on the homologous human framework.
In a preferred embodiment the human framework used is LAY.
The humanized heavy chain was designed from by inserting the murine CDRs into a human framework.
Accordingly, murine residues in the human framework region may be substituted.
The framework regions of the variable regions may be substituted by corresponding human framework regions.
In certain embodiments, the unmodified human framework is a human germline framework.
Choice of framework At the outset it was necessary to make a choice of human framework.
Optionally, the human framework sequences further comprise one or more back-mutations.
Such antibodies may have a framework sequence with high homology to the human framework sequences.
In one aspect, the frameworks are from a human framework pool of functionally expressed human antibodies.
The others called HUM are monoclonal antibodies having variable human framework regions.
According to the disclosure, the human framework regions between the CDRs are isotype matched.
Preferably the CDR regions are grafted into a human framework region.
In this case, more than one human framework template was used to design this antibody.
A humanized VHH domain may contain one or more fully human framework region sequences.
The human framework regions were chosen to maximise homology with the anti-Tac MAb sequence.
In some embodiments, the antibody comprises human framework sequences.
The human framework regions were chosen to maximize homology with the anti-Tac MAb sequence.
In preferred embodiments, the framework region is a human framework region.
It consists essentially of human framework residues and murine hypervariable residues ( outlined with a double line ).
In preferred embodiments, all of the framework region is human framework region.
A human framework sequence such as described above is best able to accept the murine-derived CDRs.
In this case, a small number of changes to the human framework sequences are made.
This universal, fully human framework can then accept one or more CDR sequences.
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