Examples of 'human germline' in a sentence
Meaning of "human germline"
Human germline refers to the genetic material (DNA) that is inherited and passed down from one generation to another through reproductive cells, such as sperm and eggs. It is distinct from somatic cells, which make up the rest of the body. Understanding the human germline is crucial in studying genetics and hereditary traits
How to use "human germline" in a sentence
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human germline
References of human germline heavy chain sequences.
Germline sequences of primary interest are human germline sequences.
Human germline sequences are found naturally in the human population.
Boxed entries represent human germline gene residues.
Human germline engineering should not be confused with gene therapy.
Dots indicate identity to the human germline sequence.
In a human germline framework.
The exchange cassette may be a human germline sequence.
Human germline modification has for many years has been heavily off limits.
Telomerase activity in human germline and embryonic tissues and cells.
At least one of the human exchange cassettes can be a human germline sequence.
Human germline genome editing poses unique and unprecedented ethical and technical challenges.
Framework regions may comprise human germline gene segment sequences.
Obviously some of the most contentious debate around gene editing involves the human germline.
Many have a blanket ban on changing the human germline that includes the technique.
See also
Human germline acceptor frameworks were chosen from sub-group VHIII and VLI.
One of the leading scientists calling for a moratorium on human germline gene editing.
A collection of human germline VI genes with this capacity is described.
Fully human frameworks are those that are identical to a known human germline framework sequence.
Alternatively, human germline sequences may be used.
This approach is based on the search for the closest human germline sequence.
Among these was human germline modification, which she strongly opposed.
Such recombinant human antibodies have variable and constant regions derived from human germline immunoglobulin sequences.
He said, ‘ The human germline is not perfect.
Recombinant human antibodies typically have variable and constant regions derived from human germline immunoglobulin sequences.
In a preferred embodiment, the human germline sequence is derived from the VK1 6 germline sequence.
References of germline sequences References of human germline kappa sequences.
The human germline framework of the VI domain may be DPK22.
Generation of Mice expressing a single rearranged human germline light chain.
Human germline acceptor frameworks were chosen from sub-groups VH3 and VK1.
Breeding of Mice expressing a single rearranged human germline light chain.
The amino acid sequences of the human germline acceptor sequences are shown in FIGS . 1A and 1B.
In some embodiments, the exchange cassette is a human germline sequence.
The closest human germline sequence was DP53.
The library scaffold is made of a set of human germline VH and VI genes.
In short, this approach compares the mouse sequence with the repertoire of human germline genes.
The FR2 region sequences of the human germline antibodies are shown below.
In some embodiments, the first and / or the second exchange cassette is a human germline sequence.
In some embodiments, the corresponding human germline sequence for the light chain J-segment is Jk2.
In certain embodiments, the unmodified human framework is a human germline framework.
Sequence alignments of each version together with human germline sequences are indicated in figure 12.
The VH-region comprised a human V-segment joined to the reference CDR3 and a human germline FR4.
Tyr 87 is present in the human germline and humanized C2VK.
The heavy chain framework residues in graft gH2 are all from the human germline gene.
SEQ ID NOS, 64 and 65 represent the human germline sequences with native CDRs.
Asterisks indicate positions of sequence identity between the mouse TFPI4F36 and human germline sequences.
It is possible that Abs that are closer to human germline would be less antigenic.
The non-human VI sequences are then aligned with each of the four human germline sequences.
In some embodiments, the FR sequences are derived from human germline light chain sequences.
The library of claim 1, wherein the exchange cassette is a human germline sequence.
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Examples of using Germline
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Germline editing could potentially do incredible things
References of human germline heavy chain sequences
Germline gene editing is banned in many countries
