Examples of 'human sequence' in a sentence
Meaning of "human sequence"
Human sequence: A phrase referring to the genetic sequence of a human being, typically used in the context of genetics or bioinformatics
How to use "human sequence" in a sentence
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human sequence
Residues identical to the human sequence are boxed.
Some human sequence antibodies of the invention are monoclonal.
Dots indicate residues found in the human sequence.
The human sequence is shown above the simian sequence.
Most of the molecule is human sequence.
Some human sequence antibodies are recombinant human sequence antibodies.
The bacterial artificial chromosome can comprise a human sequence.
Compare the human sequence with at least two other species.
Amino acid residues differing from the human sequence are boxed.
This incorporation of human sequence allows to decrease the risk of immunogenicity for therapeutic use.
The invention provides a nucleic acid encoding a heavy chain of a human sequence antibody.
The invention further provides human sequence IgA antibodies to a variety of human antigens.
There is disclosed herein a nucleic acid encoding a heavy chain of a human sequence antibody.
The introduced human sequence is removed in its entirety upon action with Cre.
All residues other than the grafted CDRs were maintained as the human sequence.
See also
In one instance, the human sequence is a λ sequence.
Rat sequences are listed only where they differ from the human sequence.
In one embodiment, the human sequence is a λ sequence.
These two oligonucleotides encoded four more changes from murine to human sequence.
In a specific instance, the human sequence is a k sequence.
Antibody preparations are obtained by fractionating blood of genetically engineered animals expressing human sequence immunoglobulins.
Some human sequence antibodies of the invention are antigen-specific.
The mouse protein sequence is shown on top and the human sequence is below.
The human sequence antibody may be well-tolerated in a patient.
Dashes indicate the same amino acids while those differing from the human sequence are indicated.
In one aspect, the human sequence comprises unrearranged immunoglobulin gene segments.
The PSCA sequence used was a full length human sequence.
In a specific embodiment, the human sequence comprises a human exon homologous to a mouse exon.
In one embodiment, the light chain comprises a human sequence.
A method for generating a human sequence antibody that binds to a predetermined antigen, the method comprising,.
In one embodiment, the heavy chain comprises a human sequence.
These may have the wild-type human sequence or may be variants of the human sequence.
In one aspect, the heavy chain comprises a human sequence.
The human sequence reported by Yang, et al.
Whenever unspecified, the human sequence is intended.
In one aspect, the plurality of immunoglobulin λ light chains comprises a human sequence.
Most preferably, the human sequence is used.
In an alternative embodiment, the variable regions or CDRs are derived from a human sequence.
In a specific embodiment, the human sequence is a k sequence.
Preferably the protein has a mammalian amino acid sequence, more preferably a human sequence.
All non-conserved residues in the human sequence were mutated to alanine.
Results are shown in Table 1 and are compared to human sequence.
Patterns of human sequence variation ( haplotypes ) thus represent ancestral DNA segments.
In one instance, the heavy chain comprises a human sequence.
Thus, in some embodiments, a human sequence is utilized as a RNA molecule of the present invention.
In one instance, the light chain comprises a human sequence.
Similarly, for the human sequence four iterations of the CTG repeats are present.
The method according to claim 15 wherein the human sequence antibodies are purified.
The human sequence revealed approximately 90 % amino acid sequence homology with the murine protein.
Therefore, mutate all non-conserved residues in the human sequence were mutated to alanine.
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