Examples of 'huntingtin' in a sentence
Meaning of "huntingtin"
Relating to, associated with, or characterized by huntingtin, a protein that is primarily found in the brain and whose mutation is linked to Huntington's disease. It can also refer to something that is influenced by or has characteristics of the protein
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- A protein whose polymorphism is associated with Huntington's disease.
How to use "huntingtin" in a sentence
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huntingtin
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
This is a microscope picture of the huntingtin protein.
Lack of huntingtin causes problems with cilia.
New antibody reveals dangerous parts of huntingtin protein.
Mutating huntingtin causes cilia problems too.
These transgenic mice do not express endogenous mouse huntingtin.
Changes in huntingtin protein levels are also measured.
Probes and primers are designed to hybridize to a huntingtin nucleic acid.
The huntingtin protein is made of glutamate.
The function of huntingtin is not known.
These transgenic mice do not express endogenouse mouse huntingtin.
Percent reduction of huntingtin mRNA levels in cynomologous monkeys.
Disclosed herein are antisense compounds targeted to a huntingtin nucleic acid.
The huntingtin protein is required for normal development before birth.
A quick recap on huntingtin lowering.
See also
Such methods employ antisense compounds which modulate the expression of huntingtin.
Pinning down huntingtin protein.
Certain embodiments provide antisense compounds targeted to a huntingtin nucleic acid.
Understanding huntingtin function.
Take out the papers and the trash and the mutant huntingtin.
Mutated huntingtin protein.
It targets only human huntingtin.
These rapid advances in huntingtin lowering treatment are starting to come quickly.
The duration of action of antisense compounds targeting huntingtin may also be evaluated.
Reductions in levels of a huntingtin protein are also indicative of inhibition of target mRNA expression.
Scientists use beams of neutrons to study the structure of clumps of mutant huntingtin protein.
This finding is unexpected since mutant huntingtin is either cytosolic or nuclear.
It is known that huntingtin is highly expressed in the central and peripheral nervous systems.
Individuals with the disease carry mutations that affect the huntingtin protein.
The effects of mutant huntingtin in neuronal cells were visualized by live cell imaging.
The disease is passed from parent to child through a mutation in the huntingtin gene.
Any new interaction of the huntingtin protein is a potential target for drug development.
The reservoir is loaded with a pharmaceutical composition comprising an antisense oligonucleotide targeted to huntingtin.
Additionally indicated is the species of huntingtin gene to which the antisense oligonucleotides are targeted.
All the antisense oligonucleotides effect significant inhibition of human huntingtin mRNA levels.
This reduces the amount of abnormal huntingtin protein that is produced by the cell.
A large number of target sequences were tested for effective knockdown of the huntingtin gene.
Antisense compounds targeted to a huntingtin nucleic acid comprise one or more modified internucleoside linkages.
There are two main reasons for trying to figure out what huntingtin looks like.
Antisense compounds for modulating expression of huntingtin are disclosed in the aforementioned published patent applications.
HD is caused by a mutation in the protein called huntingtin.
They then discovered was that the mutant huntingtin protein that causes disease was changing shape.
Compositions and their uses directed to Huntingtin.
The exact mechanisms through which the mutant huntingtin gene causes disease are not fully understood.
It is caused by an insertion of multiple CAG repeats in the huntingtin gene.
The Huntingtin gene was also one of the first disease genes to be found.
Antibodies useful for the detection of human and rat huntingtin are commercially available.
Huntingtin lowering refers to approaches that aim to lower levels of the Huntingtin protein.
One study suggests that the overabundance of glutamines in huntingtin causes rigid groupings of proteins.
Gene silencing reduces huntingtin production by preventing its RNA message being read by cells.
