Examples of 'hypomethylation' in a sentence
Meaning of "hypomethylation"
Hypomethylation refers to a process in which there is a decrease in the methylation of DNA, leading to changes in gene expression. This can have implications in various biological processes and diseases like cancer
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- a decrease in the epigenetic methylation of cytosine and adenosine residues in DNA
How to use "hypomethylation" in a sentence
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hypomethylation
The samples were analyzed for global hypomethylation.
The hypomethylation was consistent across each individual chromosome.
So we will think about the consequence of this hypomethylation.
Hypomethylation of CpG poor promoters.
Cellular differentiation is induced through the mechanism of hypomethylation.
Hypomethylation has been associated with reduced chromosomal stability and altered genome function.
The agents are also involved in tumor directed hypomethylation.
DNA hypomethylation per se is not sufficient to induce gene expression.
Because of the hypremethylation of its CpG poor promoter or hypomethylation of.
Nutritional determinants of DNA hypomethylation also have a variable effect on liver carcinogenesis.
Have both hypermethylation of the tumour suppressor genes and hypomethylation.
Hypomethylation is also observed at a number of single-copy genes.
Hypermethylation usually silences genes whereas hypomethylation leads to gene activation.
The genomic strength may be modified by removing or attenuating genomic imprinting through DNA hypomethylation.
Hypermethylation of promoters induces gene silencing while hypomethylation is associated to gene expression.
See also
Moreover, hypomethylation of fie mutants leads to the development of differentiated endosperm.
The analyses made it possible to observe the hypomethylation of the bovine semen.
Also, correlation between hypomethylation and increased gene expression was reported for many oncogenes.
Determinant of methionine synthase and DNA hypomethylation are not clear.
Global DNA hypomethylation was observed in the most socio-economically deprived subjects.
Another class of genes that might have undergone a specific hypomethylation includes the tumor suppressor genes.
Candidate enhancers were selected based on the presence of cell type specific DNA hypomethylation.
These findings suggest that the hypomethylation of the promoter results in over-expression of the enzyme.
Incorporation of decitabine into the DNA strand has a hypomethylation effect.
The inhibition of methyl transferase and hypomethylation of the DNA consequently favour a " totipotent " gene expression.
Typically, there is hypermethylation of tumor suppressor genes and hypomethylation of oncogenes.
Further more, despite causing DNA hypomethylation NaPA did not induce neoplastic transformation of transplanted 4C8 cells.
This means that as a whole in the genome, you tend to see hypomethylation.
Modifications can include both hyper - or hypomethylation of selected sites of the DNA.
For the four healthy control subjects, none of the bins showed significant hypermethylation or hypomethylation.
In these two SLE patients, hypomethylation and CNA changes were observed in plasma.
Table 4 . Enhancement of endosperm development in fie mutant seeds by hypomethylation.
Decitabine inhibits DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis.
High plasma levels of homocysteine inhibit DNA methyltransferases, which causes hypomethylation.
A hallmark of cancer genomes consists in a global DNA hypomethylation which affects especially L1 promoters.
Positive differences represent relative hypermethylation in placental DNA, negative differences relative hypomethylation.
Most tumors are reported to show global hypomethylation JG Herman et al.
TPTE transcription is initiated during the course of malignant transformation by cancer-associated DNA hypomethylation.
The green, red and grey dots represent regions with hypermethylation, hypomethylation and normal methylation, respectively.
Reversion of ddm1-induced hypomethylation is observed for regions associated with high level of 24 nt siRNA.
At 2 months after OT, there was still a significant percentage of bins showing hypomethylation changes.
Table 3 Relaxing genomic imprinting through hypomethylation can promote or prevent hybrid formation Outcome of Cross.
At the chromatin level, HMECs infected with HCMV-DB reveals a global hypomethylation state.
In this patient, cancer-associated hypomethylation was detected in the plasma.
DNA hypomethylating agents ( DHAs ) induce global and gene-specific DNA hypomethylation.
The percentage of bins showing hypomethylation ( Table 2 ) can be determined and compared to a cutoff percentage.
The first one implies L1 promoter hypomethylation.
High SOX11 expression was associated with DNA hypomethylation at SOX11 locus and favourable clinical outcome.
It is estimated that approximately 50 % of Silver Russell patients have hypomethylation of H19 and IGF2.
For the SLE patient SLE04, 84 % of the bins showed hypomethylation without in silico size fractionation.
