Examples of 'ikb' in a sentence
Meaning of "ikb"
ikb (noun) - could refer to the IκB (inhibitor of κB) protein in biological or medical contexts, known for its role in regulating gene expression and inflammation
How to use "ikb" in a sentence
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ikb
Phosphorylation of IkB by IkB kinase leads to degradation of IkB.
This kinase plays a key role in the phosphorylation of IkB.
An IkB polypeptide may be labeled.
These molecules are trapped in the cytoplasm as an inactive complex by IkB.
The phosphorylated IkB is ubiquitinated and then decomposed by proteasome.
Fractions were assayed for their activity on IkB degradation as described below.
Phosphorylation is evidenced by a slightly heavier shift in the electrophoretic mobility of IkB.
Purification of IkB kinase.
The serine phosphorylated IkB is then ubiquitinilated and degraded by the proteasome.
Another possible mechanism includes inhibition by acetylsalicylic acid of IkB phosphorylation and catabolism.
Expressed IkB polypeptides may be used without purification following in vitro translation.
Mice receiving skim milk fermented with both strains showed IkB levels comparable to controls.
IkB kinase activity assay.
The effect of compounds on the phosphorylation of IkB may be monitored in a Western blot.
Under resting conditions, NF-kB is present in the cytosol of cells as a complex with IkB.
See also
The IKK dimer then phosphorylates IkB and causes it to dissociate from NFkB.
However NIK is unable to phosphorylate IkB directly.
In other pathways, IkB kinases may not be important.
A method according to claim 7 wherein said substrate comprises a IkB polypeptide domain.
Following activation, IkB dissociates from NFkB and undergoes ubiquitination and degradation.
These results support a key role for IKKB in phosphorylation of IkB following proinflammatory stimulation.
B-lactone also blocks degradation and stabilizes the phosphorylated form of IkB.
More specifically, these compounds inhibit IkB phosphorylation and subsequent degradation.
Apparently common to all stimuli however, is the phosphorylation and subsequent degradation of IkB.
Induction of glucocorticoid expression leads to upregulation of IkB and thereby blocks NF-kB activation.
CRM1 is responsible for the nuclear export of IkB.
IkB kinase was purified from TNFa-stimulated HeLa cells.
NF-kB exists in an inactive form in the cytoplasm complexed with an inhibitor protein, IkB.
IkB directly regulates NF-kB function by keeping it sequestered in the cytoplasm.
In unstimulated cells, NF-kB exists as an inactive cytoplasmic complex with an inhibitor protein, IkB.
IkB is a cytoplasmic protein that controls NF-kB activity by retaining NF-kB in the cytoplasm.
A kinase critical to the activation of NF-kB is the IkB kinase ( IKK ).
IkB is the inhibitor of NFkB that induces the expression of pro-inflammatory pathways.
In addition, tipifarnib showed no inhibition of TNF-a induced IkB degradation in THP-1 cells.
Phosphorylation of IkB marks it for subsequent ubiquitinylation and degradation by the 26S proteosome.
I-ASP can also inhibit the transactivation function of p65, although less effectively than Ikb.
The NF-kB / Rel and IkB proteins are also likely to play a key role in neoplastic transformation.
In a particular embodiment, the binding target is a substrate comprising IkB serines 32 and / or 36.
Like NF-kB, IkB can also move into the cell nucleus.
Incubation for 90 minutes at 30°C is generally sufficient to allow phosphorylation of the IkB polypeptide.
Ubiquitinated IkB may also dissociate from the NF-kB complex, restoring NF-kB transcriptional activity.
Another pathway activates the TAK1/TAB complex, which enhances activity of the IkB kinase ( IKK ) complex.
The IkB kinases ( IKKs ), are key regulatory signaling molecules coordinating the activation of NF-kB.
Here, we disclose a novel kinase IkB Kinase, IKK-B, as a NIK-interacting protein.
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Similar results were also obtained when Ikb was co-expressed with p53 and ASP-1.
IkB protein kinases ( IKKs ) phosphorylate IkBs at specific serine residues.
In a normal cell, IkB binds nuclear factor-kB ( NFkB ) within the cytoplasm.
IkB and ubiquitinated-lkB ( UbQ-IkB ) expression were measured by Western Blotting and immunoprecipitation.
Binding of the IkB protein to NF-kB masks the nuclear localisation signal ( NIS ) of NF-kB.
