Examples of 'indolicidin' in a sentence
Meaning of "indolicidin"
Indolicidin refers to a type of antimicrobial peptide derived from the immune system of cows, known for its antibacterial properties and potential medical applications
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- An oligopeptide that shows antibacterial activity
How to use "indolicidin" in a sentence
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indolicidin
Analogues less toxic than indolicidin are preferred.
Unentrapped indolicidin was removed by passing the liposome preparations over a column.
One cationic peptide found in neutrophils is indolicidin.
The fluorescence profile of free indolicidin in the buffer was also obtained.
Cytotoxicity of free versus liposomal indolicidin.
The indolicidin and liposomes were combined at various mole ratios of lipid to indolicidin.
Such microorganisms can be eliminated by treatment with an indolicidin analog.
Also disclosed are peptide variants of indolicidin that retain the antimicrobial activity of indolicidin.
Fluorescence of aqueous indolicidin.
Indolicidin analogs can be chemically synthesized using well known methods of peptide synthesis.
Analogues that show better efficacy than indolicidin itself are preferred.
Liposomal indolicidin at the same indolicidin concentration elicited an even greater increase in survival times.
MIC values also were determined for various derivatives of indolicidin.
The resulting liposomal indolicidin formulations were then heated above their phase transition temperatures.
Figure 2 demonstrates the antimicrobial activity of indolicidin.
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Indolicidin analogs are further characterized by having substantially the same sequence as naturally occurring indolicidin.
Similarly, permeabilization by indolicidin-C was greater than that by indolicidin.
Indolicidin is a member of the cathelicidin family of antimicrobial peptides isolated from mammalian myeloid cells.
The liposome of claim 6 wherein the defensin is indolicidin.
An indolicidin analog selected from, and.
Presently, the preferred defensin is indolicidin.
An indolicidin analog can be used as a therapeutic agent, a food preservative, a disinfectant or a medicament.
An aqueous solution comprising an indolicidin analog selected from, and.
In general, it is desirable that analogues are soluble and perform better than indolicidin.
For example, indolicidin peptides can be administered in conjunction with bactenecins, defensins or antibiotics.
Fig . 8 shows single channel conductances produced by indolicidin in planar lipid bilayers.
Indolicidin concentrations were determined by dissolving liposomal preparations in ethanol and reading absorbances at 280 nm.
The inset in the figure shows the trend below indolicidin concentrations of about 5 µg / ml.
Presently, the preferred defensin for use in the liposomal formulations of this invention is indolicidin.
Furthermore, the amino acid residue at any position in an indolicidin can be independently selected.
For example, indolicidin analogs can be synthesized that have greater antimicrobial selectivity than indolicidin.
These deviations reflect changes in the intermolecular self-associations of indolicidin molecules at different indolicidin concentrations.
While indolicidin acts against many pathogens, notable exceptions and varying degrees of toxicity exist.
Representative MICs for various indolicidin analogues are shown in the Table 5 below.
Indolicidin / DOPE liposomes were prepared and used in hemolysis assays.
Structures of the indolicidin analogs are shown in Table 1.
Table 7 shows exemplary synergy data for combinations of indolicidin analogues and Mupirocin.
Examples of indolicidin analogs having such modifications are provided in Table 1.
Fig . 7 shows the voltage sign dependence of indolicidin.
The amino acid sequence of indolicidin and each of the analogs is shown in Table 1.
INDOLICIDIN ANALOGUES As noted above, there are disclosed herein indolicidin analogues.
Figure 5 compares the antimicrobial activity of indolicidin with various indolicidin analogs against C . neoformans.
An indolicidin analogue selected from,.
The liposome of claim 11 comprising about 5 mole percent indolicidin.
Administration of free indolicidin ( 2 mg / kg ) resulted in a slight increase in survival times.
Similar results were obtained with the various indolicidin analogs ( not shown ).
Initial and final indolicidin concentrations were measured by absorbance at 280 nm.
A device coated with a composition comprising an indolicidin analogue according to claims 1-8.
The indolicidin analog of claim 5, wherein said administration is topical.
The resulting oligonucleotides contained a pool of randomly mutated indolicidin sequences flanked by conserved 3 ' and 5 ' sequences.
