Examples of 'inflammasome' in a sentence
Meaning of "inflammasome"
Inflammasome (noun): Inflammasome is a multiprotein complex that plays a crucial role in the innate immune system. It is responsible for activating inflammatory responses in the body to fight off infections and maintain homeostasis
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- A multi-protein complex that is responsible for inflammatory rheumatic diseases via activation of caspases.
How to use "inflammasome" in a sentence
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inflammasome
Pyrin is a protein normally present in the inflammasome.
Role of the inflammasome pathway in atherosclerosis.
It also affects function of proteasome and inflammasome.
We did not observe any inflammasome activation induced by hyperosmolarity alone.
Pyrine may trigger the formation of a specific inflammasome.
The inflammasome is responsible for activation of many inflammatory processes.
This metabolically activated inflammatory complex is called metabolic inflammasome or metaflammasome.
Molecular mechanisms involved in inflammasome activation by aspergillus fumigatus aspergillus fumigatus.
This binding triggers a series of events leading to activation of the inflammasome.
Excessive inflammasome activation is a prominent feature of several chronic inflammatory diseases.
This review will focus on these three areas of inflammasome research.
Inflammasome activation and autophagy also interact with cellular death pathways.
This obligation triggers a series of events that lead to activation of the inflammasome.
A mutation in the gene coding of inflammasome leads to a group of autoinflammatory disease called cryopyrinopathies.
It is a scaffolding protein and is crucial for aggregating other proteins that form the inflammasome.
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The mechanisms that restrain inflammasome activation were studied in greater detail in cultured macrophages.
Our results indicate that these mutations induce a decreased threshold of activation of the pyrin inflammasome.
This inflammasome is important for host resistance against cytosolic bacteria and several dna virus.
They found that another chemical called glyburide inhibited the activation of the inflammasome proteins.
The requirement for a particular NIR within the inflammasome complex depends upon the upstream trigger.
A person infected with CHIKV has an activated molecular complex called inflammasome.
Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages.
In addition, inflammasome components were dispensable for c. neoformans uptake or killing.
It turns out that SARM is a key inflammasome regulator.
Inflammasome activation in the central nervous system, determinants and outcomes in progressive MS.
It is known to be the biggest inflammasome of all, covering about 2 um in diameter.
In addition, they ignite and develop a molecular complex called an inflammasome.
Calpains are also required for ATP-induced inflammasome activation in macrophages.
Scientists focused on the role of the cytoplasmic multi-protein complex known as the inflammasome.
However, the relationship between the nlrp3 inflammasome and breast cancer is not completely understood.
As the researchers explain, these flares are triggered by the NLRP3 inflammasome.
The team will also test how suppressing inflammasome activation affects mice with an MS-like disorder.
The researchers found genetic evidence of the involvement of a so-called inflammasome in these subjects.
Evidence indicates that NLRP3 inflammasome activation is involved in sleep regulation.
Despite its importance in combating disease, the cell biology of the inflammasome remained unclear.
Abstract, The inflammasome is thought to function as a cytosolic surveillance system against intracellular pathogens.
We found that 2 signals are required for inflammasome activation.
The trichothecene triggered inflammasome activation was dependent on the ROS production, K+ efflux and cathepsin B release.
On the other hand, hyperosmolarity shows signs of inhibiting inflammasome activation in monocytes.
In addition, NLRP3 inflammasome activation in bats is defective.
Analogous to the apoptosome, which activates apoptotic cascades, the inflammasome activates an inflammatory cascade.
The inflammasome is a multimeric structure involving a cytosolic receptor, a scaffold protein - ASC - and Caspase-1.
Our objective is to understand the Nlrp3 inflammasome in a tumoral context.
The inflammatory effects of crystalline silica are apparently mediated by the NALP3 inflammasome.
In general activation of the NLRP3 inflammasome requires two distinct signals.
Several small molecules have been shown to inhibit the NLRP3 inflammasome.
Thus, we evaluated the role of aim2 inflammasome in i . amazonensis infection.
We identified 111 proteins with a close relationship to the inflammasome.
Ethanol dose-dependently inhibited inflammasome activation and the secretion of IL-1β in human macrophages.
Here, NLRP3 actions are done independently of the other inflammasome forming proteins.
