Examples of 'intact antibody' in a sentence
Meaning of "intact antibody"
intact antibody - In biology and immunology, an intact antibody refers to an antibody molecule that has not been modified or cleaved. It is typically used to describe antibodies that remain in their original form and retain their full functionality
How to use "intact antibody" in a sentence
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intact antibody
The intact antibody was also tested as a positive control.
And wherein the targeting ligand is not an intact antibody.
An antibody containing intact antibody molecules is preferred herein.
Antigen binding functions of an antibody can be performed by fragments of an intact antibody.
The intact antibody may have one or more effector functions.
One strong protein band representing the intact antibody is visible.
The binding specificity of the intact antibody molecule is thereby reproduced on a single polypeptide chain.
Antibodies so modified have a reduced net positive charge compared to an intact antibody.
Screening for intact antibody is accomplished by ELISA assay.
The antibody has a reduced net positive charge compared to intact antibody.
Screening for intact antibody can be accomplished by ELISA assay.
The antibody fragments bind to the same antigen that is recognized by the intact antibody.
Every intact antibody can bind to cell receptors or other proteins with its Fc region.
In preferred embodiments the receptor is an intact antibody or a Fab fragment.
An intact antibody to AB.
See also
The final concentration of the antibody was determined using an Blisa that measures intact antibody.
The Fab fragment was separated from intact antibody and Fc fragments by Protein A chromatography.
In some embodiments, the immunoglobulin molecule is an intact antibody.
Thus, an intact antibody has two binding sites.
Protein A purification for removal of residual intact antibody preceded the HIC step.
An antibody containing intact antibody molecules are preferred, and are utilized as illustrative herein.
The method of claim 7 wherein said receptor is an intact antibody.
Therefore, an intact antibody has two binding sites.
Generally, an antibody fragment is derived from a parental intact antibody.
In one embodiment, the intact antibody lacks effector function.
The antigen-binding function of an antibody can be performed by fragments of an intact antibody.
Alternatively, or in addition, intact antibody can be treated with disulfide reducing agents.
Intact antibody with two sites will clear antigen, in this case IgE.
The conjugate according to either claim 1 or claim 2 wherein the antibody in an intact antibody.
An antibody containing intact antibody molecules is preferred, and is utilized as illustrative herein.
The conjugate according to either claim 1 or claim 2 wherein the antibody is an intact antibody.
In some cases, the intact antibody may have one or more effector functions.
An antigen-binding fragment competes with the intact antibody for specific binding.
An intact antibody has primarily two regions, a variable region and a constant region.
In other embodiments, humanized variable regions make-up the variable region of an intact antibody.
Preferably, the intact antibody has a functional Fc region.
The term antibody includes antigen-binding portions of an intact antibody that retain capacity to bind.
Optionally, the intact antibody has a functional Fc region.
For example, Fab fragments are prepared by enzymatic cleavage of intact antibody.
Thus, in general, an intact antibody has two binding sites.
However, the inhibitory activity of the Fab was slightly less potent than the intact antibody.
In one embodiment, the intact antibody is an anti-EGFR antibody, such as cetuximab.
An “ antibody fragment ” comprises at least a portion of an intact antibody.
The intact antibody is produced by Chinese Hamster Ovary ( CHO ) cells.
An antigen-binding portion competes with the intact antibody for specific binding.
The term “ peptibody ” refers to a peptide or polypeptide which comprises less than a complete, intact antibody.
By 35 days, a minor amount of intact antibody is released.
As used herein, the term " antibody fragments " refers to a portion of an intact antibody.
Such embodiments can include an intact antibody comprising such an F ( ab ' ) 2.
The term “ antibody fragments ” means a portion of an intact antibody.
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Examples of using Intact
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Use approved and intact wall sockets
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