Examples of 'irna' in a sentence
Meaning of "irna"
Irna (noun): A proper noun which could refer to a name of a person or organization
How to use "irna" in a sentence
Basic
Advanced
irna
A free iRNA is administered in the absence of a pharmaceutical composition.
The aqueous portion contains the iRNA composition.
The free iRNA may be in a suitable buffer solution.
These methods are readily adapted to packaging iRNA agent preparations into liposomes.
The iRNA agent may target multiple transcript variants e.
Liposomes that include iRNA can be made highly deformable.
The iRNA agents can be chemically synthesized or expressed from a vector or enzymatically synthesized.
Sufficient for expression of the iRNA in the desired target cell or tissue.
Too much iRNA in the inoculum reduces the virus yield to unusable amounts.
Viral vectors that contain nucleic acid sequences encoding an iRNA can be used.
A liposome containing an iRNA agent can be prepared by a variety of methods.
The formation of vesicles or micelles further prevents degradation of the iRNA when administered systemically.
An appropriate control iRNA is also administered as a control as is routine in the art.
Several studies have shown successful knockdown of gene products when an iRNA is administered locally.
Such formulations with iRNA agent are useful for treating a dermatological disorder.
See also
Such a modification usually favors recognition of the iRNA by the DICER complex.
One or more of the nucleotides of an iRNA may also include a hydroxymethyl substituted nucleotide.
The iRNA agent preparation is then added to the micelles that include the lipid component.
I do not think Irna liked actors.
The iRNA includes a sense strand having a first sequence and an antisense strand having a second sequence.
She began her career in working for Irna Phillips.
Delivery of an iRNA The delivery of an iRNA to a cell e.
Television series created by Irna Phillips.
An iRNA agent can also be a DNA transcribable into an RNA.
This is my colleague Irna Frey.
Serpina1 iRNA compositions and methods of use thereof.
Additionally or alternatively, some nucleobases of an iRNA molecule may be present as desoxyriboses.
In one embodiment, an iRNA of the invention is conjugated to a carbohydrate through a linker.
In other cases, all of the nucleotides of an iRNA of the invention are modified.
In another case, an iRNA agent is administered to a subject as a fixed dose.
In one preferred embodiment, expression of the gene or homologue is disrupted by iRNA.
In another embodiment, an iRNA agent is administered to a subject as a fixed dose.
Irna didn't have better vision than anyone else who ate their vitamins.
In some embodiments, a modified iRNA will have a phosphorus atom in its internucleoside backbone.
Preferably, the RGD peptide will facilitate targeting of an iRNA agent to the kidney.
In one case, an iRNA of the invention is conjugated to a carbohydrate through a linker.
Constructs for the recombinant expression of an iRNA will generally require regulatory elements, e.
The iRNA agents can be unmodified or chemically-modified nucleic acid molecules.
A detailed discussion by Irna appears here,.
In one embodiment, an iRNA as described herein contains no more than 3 mismatches.
In one case, the RNA of the iRNA e.
In some embodiments, an iRNA forms a complex with cyclodextrin for systemic administration.
Do not go soft on me, Irna.
A composition comprising an iRNA agent comprising a sense strand and an antisense strand, wherein,.
Expression of an ALAS1 gene is reduced or inhibited using an ALAS1-specific iRNA.
The iRNA of claim 7, wherein the sense and antisense sequences are stabilized against nucleolytic degradation.
The series was created by Irna Phillips, who based it on personal experiences.
An iRNA as described herein effects inhibition of ALAS1 expression in a cell or mammal.
The disclosure describes methods and iRNA compositions for modulating the expression of an ALAS1 gene.
The iRNA may target a particular transcript variant of ALAS1 e.
