Examples of 'irreversible inhibitors' in a sentence
Meaning of "irreversible inhibitors"
irreversible inhibitors - Substances that permanently deactivate enzymes or biochemical processes
How to use "irreversible inhibitors" in a sentence
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irreversible inhibitors
Also described herein are irreversible inhibitors of ACKs.
Irreversible inhibitors are usually alkylating substances.
Suicide and irreversible inhibitors.
A reversible inhibitor presents a more attractive therapy than irreversible inhibitors.
They may also be irreversible inhibitors of protein tyrosine kinases.
It is considered to be a class of irreversible inhibitors.
Irreversible inhibitors usually react with the enzyme and change it chemically.
These compounds therefore constitute irreversible inhibitors of these enzymes.
Irreversible inhibitors based on the analogous tetrapeptide recognition sequence have been prepared.
Examples of irreversible inhibitors.
Irreversible inhibitors are similar to competitive inhibitors as they both bind to the active site.
The disclosure provides for trypsin inhibitors that are irreversible inhibitors or reversible inhibitors.
Not all irreversible inhibitors form covalent adducts with their enzyme targets.
Also described herein are irreversible inhibitors of Btk.
The irreversible inhibitors employed in the present methods and compositions are specific for serine proteases.
See also
Certain peptidyl epoxy ketones such as EST are irreversible inhibitors of the proteasomes.
The irreversible inhibitors would be more desirable because they could block the protease activity permanently.
Published a description of these methods for measurement of rate constants of irreversible inhibitors of ICE.
Ssuch irreversible inhibitors may be selective for Btk.
Furthermore, the compounds are observed to be irreversible inhibitors.
Also described herein are irreversible inhibitors of Btk tyrosine kinase cysteine homologs.
These tight-binding inhibitors may show kinetics similar to covalent irreversible inhibitors.
The structures of the irreversible inhibitors are shown below,.
Two types of MetAP2 inhibitor also exist, reversible inhibitors and irreversible inhibitors.
There are two categories of inhibitors - irreversible inhibitors and reversible inhibitors.
Irreversible inhibitors usually covalently modify an enzyme, and inhibition can therefore not be reversed.
Examples of active-site-directed irreversible inhibitors include phosphate or phosphonate esters.
Second-order rate constants for inactivation of ICE and ICE homologs with irreversible inhibitors are obtained.
Preferred irreversible inhibitors for serine proteases are PMSF, pAPMSF, and DFP.
Also described herein are irreversible inhibitors of HER4.
Irreversible inhibitors are preferred ; reversible inhibitors ( competitive and non-competitive ) can also be used.
In further cases, the multiplicity of test irreversible inhibitors is a panel of test irreversible inhibitors.
Irreversible inhibitors can be classified into three categories, group-specific reagents, substrate analogs, and suicide inhibitors.
Organophosphorus agents ( OPs ) are irreversible inhibitors of acetylcholinesterase ( AChE ).
The irreversible inhibitors include for example epoxides such as E64, a-halo ketones, and disulfides.
However, substantial toxicity of these irreversible inhibitors has been demonstrated Kruger E.A., Exp.
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