Examples of 'is cleavable' in a sentence
Meaning of "is cleavable"
is cleavable: this phrase implies that something can be easily split, divided, or separated along certain lines or planes, suggesting a property of being prone to cleave or break apart
How to use "is cleavable" in a sentence
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is cleavable
X is a cleavable linker that is cleavable under physiological conditions.
The pyridyl disulfide product is cleavable.
Is cleavable by the action of an enzyme.
The amino acid linker sequence is cleavable by proteolytic activity.
The MMP cleavage site comprises peptide sequences having a peptide bond that is cleavable by a MMP.
The cleavable bond is of a type which is cleavable by exposure to concentrated aqueous ammonia.
Most preferably the expression cassette encodes a cleavable peptide linker that is cleavable with clostripain.
The linker X is cleavable under physiological conditions.
A linker can include a cleavable linking group that is cleavable by a particular enzyme.
The linker is cleavable by a protease ; or.
Preferably the expression cassette encodes a cleavable peptide linker that is cleavable with cyanogen bromide.
Is a dipeptide that is cleavable by the action of cathepsin ;.
More preferably the expression cassette encodes a cleavable peptide linker that is cleavable with palladium.
Preferably, the secretion signal sequence is cleavable and is removed from the mature binding agent.
The MMP cleavage site may comprise any amino acid sequence which is cleavable by a MMP.
See also
In at least some embodiments, R3 is cleavable in vivo to provide an active drug compound.
In one such aspect, the linker is cleavable.
The latter is cleavable with reducing agents, DSS is a nonreversible crosslinker.
Preferably the expression cassette encodes a cleavable peptide linker that is cleavable with a tissue specific protease.
The bond or linker L is cleavable in vivo so as to release the active agent A ′.
In some cases, a tag sequence is cleavable.
Compound according to claim 2 wherein the bond is cleavable by a human glycosidase, preferentially human B-glucuronidase.
A molecule according to claim 6 wherein said linker is cleavable.
Preferably, the protecting group is cleavable bound vÃa a covalent bond.
FCS comprises a furin cleavage sequence of amino acid residues, which sequence is cleavable by furin ;.
In preferred embodiments, a linker X is cleavable under physiological conditions.
The MMP cleavage site comprises a peptide sequence having a peptide bond, that is cleavable by a MMP.
In some embodiments, the labile bond is cleavable by biochemical hydrolysis, proteolysis, or sulfhydryl cleavage.
In yet another example, a spacer may contain a hydrozone bond which is cleavable under acidic pH.
In yet other embodiments, the linker is cleavable under reducing conditions ( for example, a disulfide linker ).
The toxic agents and receptor may be linked, usually by a bond which is cleavable cytoplasmically.
In one embodiment, L1 is cleavable by the action of an enzyme.
In the most preferred embodiment, the linkage is cleavable by CID.
In yet other embodiments, the linker is cleavable under reducing conditions ( e.g., a disulfide linker ).
In some cases, the linker is cleavable.
In the present disclosure, the linker is cleavable under reducing conditions ( e.g., a disulfide linker ).
A process according to claim 12, wherein the cross-linking agent is cleavable by periodate.
In some embodiments, the labile bond is cleavable under in vivo conditions.
The multimeric ApoA-I agonist of Claim 1 or 2 in which the bifunctional linker is cleavable.
In one embodiment, the linker is cleavable by a protease.
A process according to claim 12, wherein the cross-linking agent is cleavable by acid.
In preferred embodiments, the labile bond is cleavable under in vivo conditions.
A process according to claim 12, wherein the cross-linking agent is cleavable by base.
Thus, in one embodiment, the capping group is cleavable by the action of an enzyme.
The immunoconjugate of claim 13, wherein the linker is cleavable by a protease.
Is a Stretcher unit ; and is a dipeptide that is cleavable by the action of cathepsin.
The conjugate of claim 3, wherein the conjugate is cleavable by a protease.
Finally the linker ( disulfide ) is cleavable by for example DTT.
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Examples of using Cleavable
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Other cleavable linkers require hydrogenolysis or photolysis
Suitable proteolytically cleavable linkers are described above
Such cleavable fluorogenic substrates are commercially available
