Examples of 'is pegylated' in a sentence
Meaning of "is pegylated"
is pegylated - a term used in pharmaceuticals to describe the attachment of a polyethylene glycol (PEG) polymer to a drug molecule. This process is done to improve the drug's properties such as stability, solubility, and half-life in the body
How to use "is pegylated" in a sentence
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is pegylated
It is pegylated to protects the molecule from breakdown.
In one example the glucagon peptide is pegylated.
Also preferred is pegylated consensus interferon.
In one embodiment the glucagon peptide is pegylated.
Currently, the preferred treatment is pegylated interferon together with ribavirin.
In some embodiments, the introduced cysteine is pegylated.
Insulin is PEGylated by use of a linear 20 kD PEGylation reagent containing an aminooxy group.
In some aspects the antibody is PEGylated.
For example, relaxin polypeptide is PEGylated with an alkyne-terminated mPEG derivative.
In some embodiments, the antibody is PEGylated.
HGH is PEGylated by use of a linear 20 kD PEGylation reagent containing an aminooxy group.
In some embodiments, argininosuccinate synthetase is PEGylated.
In certain embodiments, the thymosin peptide is pegylated to increase its half-life in circulation.
A monovalent antibody of claim 4 which is pegylated.
GH-GHBP complex is PEGylated in the same manner to give a derivative of 150K by gel filtration.
See also
In some embodiments, a bispecific antibody is PEGylated.
The active substance is PEGylated B-domain deleted recombinant human coagulation factor VIII ( damoctocog alfa pegol ).
In some embodiments, the peptide is PEGylated.
Preferably a fragment is pegylated or encapsulated ( e.g. for stability and / or sustained release ).
In the methods provided herein, the hyaluronan degrading enzyme is PEGylated.
In other embodiments, the soluble cytokine receptor is pegylated to increase its serum half-life.
Preferable, in the use described above, the erythropoietin protein is pegylated.
In yet another embodiment, the interferon is pegylated alpha interferon 2a or 2b.
In the methods disclosed herein, the hyaluronan degrading enzyme is PEGylated.
It is pegylated with a branched 40 kg / mol PEG chain.
The compound of any of the preceding claims, wherein the compound is PEGylated.
For example, FGF-21 polypeptide is PEGylated with an alkyne-terminated mPEG derivative.
The method according to claim 1, wherein the recombinant oxalate oxidase is pegylated.
The modified human ciliary neurotrophic factor of claim 1, which is pegylated with polyethylene glycol.
In an embodiment, there is provided an isolated antibody, wherein the isolated antibody is pegylated.
The composition of Claim 7 wherein the PEG-MGDF is pegylated with polyethylene glycol.
In another embodiment, the cartilage differentiation and maintenance factor of the present invention is pegylated.
A method according to Claim 21 wherein the PEG-MGDF is pegylated with polyethylene glycol.
The mutant CocE polypeptide of claim 1, wherein the mutant CocE polypeptide is pegylated.
The composition for use according to claim 1 wherein said arginase is pegylated recombinant human arginase.
A protein or polypeptide in accordance with any one of XL or XLI, which is pegylated.
In one embodiment, a fibronectin based scaffold protein is pegylated at the C-terminus.
In a preferred embodiment the polypeptide is purified as a single chain FVII, which further is PEGylated.
The use according to claim 5 wherein the interferon is pegylated interferon alpha-2a.
The prodrug or salt thereof according to claim 1 wherein said drug D is pegylated.
In some embodiments, a PEG-modified or PEGylated lipid is PEGylated cholesterol or PEG-2K.
The composition of claim 1, wherein each of the MHC class I peptide epitopes is pegylated.
In some embodiments, the Fc region is PEGylated.
The polypeptide of any one of claims 1 to 7, wherein the polypeptide is PEGylated.
In preferred embodiments, the G-CSF is pegylated.
An immunoconjugate according to any of Claims 4-6, wherein the immunoconjugate is pegylated.
The composition of Claim 6 wherein the chemically modified MGDF is pegylated MGDF ( PEG-MGDF ).
The method of claim 2, wherein the monovalent antibody is pegylated.
The method described in paragraph 42, wherein the IFN-alpha is pegylated interferon-alpha.
The method of claim 1, wherein the peptide is pegylated.
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Examples of using Pegylated
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Combination therapy with pegylated liposomal doxorubicin
Pegylated bovine granulocyte colony stimulating factor
Damoctocog alfa pegol is a PEGylated form of rFVIII
