Examples of 'its active metabolite' in a sentence
Meaning of "its active metabolite"
its active metabolite - It refers to the biologically active form of a compound that is produced as a result of metabolic processes in the body. It is the transformed or modified version of the original substance that contributes to the desired physiological effects
How to use "its active metabolite" in a sentence
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its active metabolite
Macitentan and its active metabolite.
Selexipag is rapidly absorbed and is hydrolysed by carboxylesterases to its active metabolite.
Measure its active metabolite.
Dialysis has no effect on the exposure of patients to lumiracoxib or its active metabolite.
Flutamide and its active metabolite were not well dialyzed.
Dronedarone does not affect the pharmacokinetics of clopidogrel and its active metabolite.
Selexipag and its active metabolite do not inhibit transport proteins.
A amidase capable of converting acephate or an analogue of acephate to its active metabolite methamidophos.
Loratadine and its active metabolite are excreted in the breast milk of lactating women.
Effects of other medicinal products on the pharmacokinetics of parecoxib or its active metabolite valdecoxib.
The pharmacokinetics of macitentan and its active metabolite have mainly been documented in healthy subjects.
Patients with a history of acute pancreatitis after administration of carbimazole or its active metabolite thiamazole.
The pharmacokinetics of selexipag and its active metabolite have been studied primarily in healthy subjects.
These patients may have higher plasma concentrations of amitriptyline and its active metabolite nortriptyline.
Effect of parecoxib ( or its active metabolite valdecoxib ) on the pharmacokinetics of other medicinal products.
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Famciclovir needs aldehyde oxidase to be converted into penciclovir, its active metabolite.
It is unknown whether oseltamivir or its active metabolite are excreted in human milk.
Since its active metabolite is not a potassium channel blocker, no cardiotoxicity is associated with fexofenadine.
The pharmacokinetics of macitentan and its active metabolite were not affected by warfarin.
An exposure-QT analysis suggested a concentration-dependent increase in QTcF for apalutamide and its active metabolite.
The pharmacokinetics of selexipag and its active metabolite are not affected by warfarin.
D Five weeks is necessary because of the long half-life of fluoxetine and its active metabolite.
Salts of levosimendan or its active metabolite ( II ) may be prepared by known methods.
Nevertheless, this was not observed for ebastine specifically for its active metabolite carebastine.
Minimal conversion of Ksart to its active metabolite was seen in about 1 % of individuals studied.
Four to ten mikes per mil, but you also have to measure its active metabolite.
Tramadol and its active metabolite M1 exhibit a low and selective affinity for µ opioid receptors.
Cefpodoxime proxetil is a prodrug ; its active metabolite is cefpodoxime.
Selexipag and its active metabolite do not inhibit cytochrome P450 enzymes at clinically relevant concentrations.
Chlordiazepoxide has a medium to long half-life but its active metabolite has a very long half-life.
Its active metabolite is a substrate for OATP1B1.
C iclesonide is an ester prodrug and is converted to its active metabolite M1 by esterases.
Selexipag and its active metabolite both undergo oxidative metabolism by CYP2C8 and CYP3A4.
Codeine is a prodrug which is converted to its active metabolite morphine by the enzyme CYP2D6.
However, its active metabolite half-life is only 8 hours.
Additionally, a significantly increased Tmax for venlafaxine and its active metabolite was found.
Peak concentrations of losartan and its active metabolite are reached in 1 h and in 3 to 4 h, respectively.
Codeine is metabolized by the liver enzyme CYP2D6 into morphine, its active metabolite.
Steady-state conditions of macitentan and its active metabolite are achieved after 3 days and 7 days, respectively.
Prior to absorption there is extensive conversion of BDP to its active metabolite B-17-MP.
Selexipag is hydrolysed to its active metabolite by carboxylesterases ( see section 5.2 ).
The protein binding of simvastatin and its active metabolite is > 95.
Selexipag is hydrolysed to its active metabolite by hepatic carboxylesterase 1 CES1 ; see section 5.2.
The terminal half-life of losartan is 2 hours and its active metabolite is 6-9 hours.
Losartan Both losartan and its active metabolite are ≥ 99 % bound to plasma proteins, primarily albumin.
Four to 10 mics per mil . Measure its active metabolite.
Selexipag and its active metabolite are substrates of OATP1B1 and OATP1B3.
Under desogestrel is also to understand its active metabolite 3-keto-desogestrel.
Clopidogrel is converted into its active metabolite vía, inter alia, the polymorphic enzyme CYP2C19.
In poultry enrofloxacin is poorly metabolized to its active metabolite ciprofloxacin ( approximately 5 % ).
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Examples of using Metabolite
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The major metabolite of vortioxetine is pharmacologically inactive
Homocysteine is a key junction metabolite in methionine metabolism
The main metabolite is characterised as toltrazuril sulfone
Examples of using Active
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She had active orthodontic treatment as a teenager
Integral person member active in his environment
It has active community support and acceptance
