Examples of 'leptin receptor' in a sentence
Meaning of "leptin receptor"
leptin receptor - A type of cell surface receptor that binds to the hormone leptin. Leptin receptors play a key role in regulating appetite and energy balance in the body
How to use "leptin receptor" in a sentence
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leptin receptor
Leptin receptor is also upregulated by proinflammatory signals.
Fasting increases leptin receptor activity.
Tissue distribution of the alternatively spliced leptin receptor.
The leptin receptor is found on a wide range of cell types.
A defect in the leptin receptor.
A defective leptin receptor has been postulated to be involved in obese patients.
There is also disclosed an antigenic fragment of the leptin receptor.
Leptin receptor deficient mice do not know the feeling of fullness.
These mice are characterized by having a point mutation in the leptin receptor.
Leptin receptor expressing cells were grown and collected by low speed centrifugation.
The db locus has been shown to code for the leptin receptor.
He found that the leptin receptor is similar to other receptors of the same family.
At least six different splice variants of the human leptin receptor were found at present.
The human leptin receptor is expressed at the cell surface of many different tissues.
Such a method may be used for screening leptin receptor agonists or antagonists.
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Activation of the leptin receptor by binding of leptin plays a role in several physiological processes.
These cDNAs were found to correspond to five different splice variants of the leptin receptor.
Generation of the leptin receptor mutants was described by Eyckerman et al.
The invention is also directed to an antibody specific for the claimed leptin receptor.
In one specific embodiment, the leptin receptor is a human leptin receptor.
A functional fragment as used here is a fragment that still can bind to the leptin receptor.
Recently, a second promoter for the leptin receptor has been discovered.
The invention is also directed to an isolated nucleic acid encoding the claimed leptin receptor.
Method for screening leptin receptor agonists or antagonists comprising the steps of,.
This assay measures receptor signaling following treatment of cells expressing a modified Leptin receptor.
Alternatively, the leptin receptor comprises a transmembrane domain, and is an integral membrane protein.
Isoform B is the longest variant of the leptin receptor.
The leptin receptor is a membrane-bound receptor which has an extracellular leptin binding domain.
Sometimes, leptin resistance is caused by a malfunction of the brain 's leptin receptor.
The db / db mice have defective leptin receptor and show hyperglycemia with significant weight gain.
In another aspect, there is disclosed an antibody specific for a leptin receptor.
In another embodiment, the leptin receptor is a human leptin receptor comprising conservative amino acid substitutions.
In either event, the polypeptide functions as a leptin receptor by binding to leptin.
Surprisingly, the human leptin receptor differentiates selectively between non-mutated leptin and mutated leptin.
Because of alternative splicing processes, there are several isoforms of the leptin receptor.
The interaction sites of SOCS3 with the leptin receptor were confirmed using a biochemical approach.
In one embodiment, an agent treating the endocrine system is a leptin receptor agonist.
The mutant leptin receptor ( long isoform ) is indicated as mIR.
In a similar manner, peptides can be found that regulate the leptin receptor.
The murine leptin receptor contains three tyrosine residues within its cytoplasmic domain ( Fig.2A ).
Method for determining the binding of a compound to a leptin receptor comprising the steps of,.
Leptin receptor deficient mice db / db ; BKS.
For example, an obese mutant mouse called diabetic has a leptin receptor deficiency.
Leptin receptor activation inhibits neuropeptide Y ( NPY ) and agouti-related peptide ( AgRP ), and activates α-melanocyte-stimulating hormone α-MSH.
In another specific embodiment, exemplified infra, the leptin receptor is a murine leptin receptor.
According to a most preferred variant of the invention, the first detection reagent is a leptin receptor.
FIGURE 1 . Localization of the leptin receptor to the region of the db gene.
In addition, both the first and the second detection reagent can be a leptin receptor.
FIG . 2 d shows the human leptin receptor sequence of isoform D.
In a similar manner, one can screen for bioactive species which regulate the leptin receptor.
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Examples of using Leptin
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The administration of leptin establishes susceptibility to autoimmunity
Leptin is also a product of the obese gene
Identification of targets of leptin action in rat hypothalamus
Examples of using Receptor
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Receptor is not sensitive to the type of change
Is that why that receptor network existed
This receptor can exist in three conformations
