Examples of 'lesinurad' in a sentence
Meaning of "lesinurad"
lesinurad (adjective): Likely associated with a chemical compound, drug, or substance with specific pharmacological properties. This term might be utilized in pharmaceutical research, medicine, or related scientific disciplines
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- A urate-transporter inhibitor used to treat hyperuricemia associated with gout.
How to use "lesinurad" in a sentence
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lesinurad
Lesinurad does not accumulate following multiple doses.
Zurampic contains the active substance lesinurad.
Effect of lesinurad on other medicinal products.
The active substances are allopurinol and lesinurad.
A causal relationship with lesinurad has not been established.
Duzallo contains the active substances allopurinol and lesinurad.
Crystalline forms of lesinurad and its sodium salt.
Duzallo contains the active ingredients allopurinol and lesinurad.
The effect of lesinurad on fertility in humans has not been studied.
There are no data from the use of lesinurad in pregnant women.
Lesinurad is quickly and practically completely absorbed from the gut.
Metabolites are not known to contribute to the uric acid lowering effects of lesinurad.
Studies in animals with lesinurad do not indicate direct or indirect harmful effects.
In male and female rats, there was no effect on mating or fertility with lesinurad.
The effect of lesinurad and allopurinol on fertility in humans has not been studied.
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What Zurampic contains - the active substance is lesinurad.
Lesinurad is a urate lowering therapy in clinical development for the treatment of gout.
The mean steady state volume of distribution of lesinurad was approximately 20 L following intravenous dosing.
Lesinurad is also under review in the United States.
HMG-CoA reductase inhibitors that are sensitive CYP3A substrates may interact with lesinurad.
Lesinurad sodium for use as claimed in claim 5.
The absolute bioavailability of lesinurad is approximately 100.
Lesinurad is a white to off-white powder and is not hygroscopic.
In rats, there was no effect on mating or fertility with lesinurad see section 5.3.
Lesinurad enhances urate excretion by inhibition the tubular re-absorption.
The elimination half-life ( t ½ ) of lesinurad was approximately 5 hours following a single dose.
Lesinurad sodium and allopurinol for use as claimed in claim 1.
The most common adverse reaction leading to discontinuation of lesinurad was blood creatinine increased ( frequency 0.8 % ).
Lesinurad or a pharmaceutically acceptable salt thereof ; and a pharmaceutically acceptable excipient or carrier.
By inhibiting URAT1, lesinurad increases uric acid excretion and thereby lowers serum uric acid sUA.
Lesinurad sodium for use as claimed in claim 6 wherein the thiazide diuretic is hydrochlorothiazide.
Duzallo contains lesinurad and allopurinol, two anti-hyperuricemic active substances with complimentary mechanisms of actions.
Lesinurad is a selective uric acid reabsorption inhibitor that inhibits uric acid transporter URAT1.
Unchanged lesinurad in urine accounted for approximately 30 % of the dose.
Lesinurad inhibits URAT1, a protein that is responsible for reabsorption of uric acid in the kidneys.
In addition, lesinurad is an in vitro inducer of CYP2B6 and CYP3A via CAR / PXR.
Lesinurad exposure is increased when it is co-administered with inhibitors of CYP2C9.
Lesinurad also inhibits OAT4, a uric acid transporter involved in diuretic-induced hyperuricaemia.
Lesinurad also inhibits organic anion transporter ( OAT ) 4, a uric acid transporter involved in diuretic-induced hyperuricemia.
With lesinurad in combination with allopurinol - Pooled data from CLEAR1 and CLEAR2 studies.
Lesinurad ( a medicine to treat gout ).
Lesinurad is extensively bound to proteins in plasma ( greater than 98 % ), mainly to albumin.
Lesinurad is a mild to moderate inducer of CYP3A see section 4.5.
Lesinurad has been authorized in the EU as Zurampic since 2016.
