Examples of 'lipophilicity' in a sentence
Meaning of "lipophilicity"
Lipophilicity: A noun referring to the ability of a chemical compound to dissolve in fats, oils, and lipids
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- The condition of being lipophilic
- A measure of the extent to which something is lipophilic
How to use "lipophilicity" in a sentence
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lipophilicity
Lipophilicity is a desirable characteristic for a resistance modulator.
Increase in chlorination increases both stability and lipophilicity.
Due to their lipophilicity they are distributed to organs rich in fat.
Good ink assimilation and lipophilicity.
Increased lipophilicity of the carrier also results in a rate increase.
Such substituent may be a group or functionality imparting hydrophilicity or lipophilicity.
This is said to be a function of the lipophilicity and pKa of timolol.
Nitroxide lipophilicity can be controlled by the addition of various organic substituents.
Partition coefficients are a measurement of lipophilicity.
Due to the lipophilicity.
The low amount of oil binding demonstrates its poor lipophilicity.
Meyer concluded that lipophilicity was the essential factor in the effectiveness of an anaesthetic.
In this respect the limiting factor is the pronounced lipophilicity of silibinin.
The high lipophilicity and high polarity are properties key to this application.
Phenoperidine was determined to have decreased stability and enhanced lipophilicity compared to pethidine.
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Therefore a low clearance and lipophilicity is an essential feature for therapeutic applicability.
These analogs also can be evaluated for aqueous solubility as well as lipophilicity.
It has a greater lipophilicity than tacrolimus with a stronger affinity with the skin.
A lot of researchers have been trying to discover molecules that have a property of high lipophilicity.
The minimum lipophilicity requirement for the outer block must still be met.
A prodrug with good permeation across biological membranes should exhibit optimum lipophilicity.
Compounds of high lipophilicity are more strongly bound to proteins than compounds of low lipophilicity.
An important role in formulating therapeutic compositions containing cyclosporin is played by their high lipophilicity.
Such lipophilicity is required to ensure adequate diffusion of the precursor through the device.
Results indicate that simply raising lipophilicity is not sufficient to increase paracellular transport.
The lipophilicity of the compounds was substantially higher than that of the parent drug.
An important role in formulating therapeutic compositions containing cyclosporins is played by their high lipophilicity.
Increasing the lipophilicity of these compounds does not appear to improve brain uptake in rats.
The restraining portion may advantageously have a negative charge and may have low lipophilicity.
The isosteres have varying lipophilicity and may contribute to enhanced metabolic stability.
The results demonstrated a strong correlation between antimicrobial potency and overall lipophilicity of the compounds prepared.
Lipophilicity is a major structural factor that influences the pharmacokinetic and pharmacodynamic behavior of compounds.
Log D is a parameter that reflects the lipophilicity of a compound at physiological pH.
Lipophilicity was the first of the descriptors to be identified as important for CNS penetration.
The log P values is also known as a measure of lipophilicity of a compound.
In these studies, lipophilicity of imaging agents was characterized by computed logP.
These properties are commonly dependent on the lipophilicity of the compound Coimbra et al.
Advantageously, quinols of the invention demonstrate decreased lipophilicity.
To provide lipophilicity the alkyl chain should be 5 or more carbons.
When compared with GUDCA and TUDCA the lipophilicity is slightly higher.
Therefore, its lipophilicity is poor, and its affinity to an organic medium is lower.
However, these compounds display a high lipophilicity.
Despite its excellent activity, high lipophilicity of ch8 hampers its administration.
In another embodiment, a drug is covalently modified to increase its lipophilicity.
Lipophilicity can be determined using the octanol, water partition coefficient as model of membranes.
To each vial add 1 g of the fluid to be tested for lipophilicity.
Significantly, the lipophilicity of the diluent is less than the lipophilicity of the composition.
In certain embodiments, the excipient increases the lipophilicity of the drug.
Preferably, the bulk and lipophilicity of one or more amino acid residues is increased.
To each vial add 1 g of the solvent or fluid to be tested for lipophilicity.
