Examples of 'liver-specific' in a sentence
Meaning of "liver-specific"
Liver-specific is an adjective used in biology or medicine to describe something that is targeted or restricted to the liver. It indicates a focus on the liver or its functions
How to use "liver-specific" in a sentence
Basic
Advanced
liver-specific
One possibility would be a liver-specific promoter.
This is a liver-specific cell that is the start of the tumor.
In addition, albumin secretion was monitored as an indicator of liver-specific functions.
Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes.
Several enhancer sequences for liver-specific genes have been documented.
Liver-specific nucleic acid regulatory elements and methods and use thereof.
Liver cells rapidly lose liver-specific functions when placed in culture.
According to a further embodiment, the viral promoter is a liver-specific viral promoter.
Two of these liver-specific enhancer elements are used in combination with the promoter.
An example would be a liver cell that no longer makes liver-specific proteins.
At that time, gene expression of each of liver-specific secretory proteins and cytokines was evaluated.
According to yet a further specific embodiment, the promoter is a human liver-specific promoter.
Liver-specific promoters are particularly preferred for use in conjunction the non-erythroid deaminase.
Clearly, this suggests an optional role for liver-specific transcription factors.
MRI with liver-specific contrast has become a true landmark in this field.
See also
However, the function of these two presumptive liver-specific sequences remains to be investigated.
Said nucleic acid is operably linked to a promoter, especially an ubiquitous or liver-specific promoter.
Hepatic stellate cells are liver-specific pericytes and exist in close proximity with endothelial cells.
But these can also occur without such liver-specific risk factors.
The liver-specific promoter may or may not be a hepatocyte-specific promoter.
For example, two identical enhancers may be combined with a liver-specific promoter.
Production of TGFB, fibrinogen and other liver-specific proteins by the cultured hepatocytes is also observed.
Transcription factor binding sites associated with the highest liver-specific gene expression.
According to the invention, the liver-specific promoter is an inducible liver-specific promoter.
According to a further element of the specification, the viral promoter is a liver-specific viral promoter.
Tissue-specific enhancers, such as liver-specific enhancers, may be used in some embodiments.
According to a particular element of the specification, the gene therapy envisaged is liver-specific gene therapy.
Tissue-specific promoters, such as liver-specific promoters, may be used in some embodiments.
Moreover, such cell population can be further differentiated into cells presenting liver-specific activities.
The promoter is preferably a mammalian liver-specific promoter, in particular a murine or human liver-specific promoter.
Moreover, such cell populations can be further differentiated into cells presenting liver-specific activities.
A liver-specific promoter comprising a first response element of no more than 160 nucleotides in length that comprises,.
The disclosed promoters can be utilized in any situation where liver-specific transcription is desired.
The product is stable over time, its liver-specific functions remaining unaltered > 8 weeks, and upon cryopreservation.
Said triple repeat and said regulatory element being operably linked to a liver-specific promoter and a transgene.
There are many liver-specific promoters described in the literature ( See supra ).
Cells of the present invention also possess, express and maintain these liver-specific physiological / biochemical reactions.
Expression of various liver-specific and other genes was studied on sorted cells from R3-5.
In addition, we have generated transgenic mice ovorexpressing BAFF under the control of a liver-specific promoter.
A conditional knockout was generated by expressing a liver-specific inducible dominant negative IkBa transgene I.
In one embodiment, the transcription regulatory sequence comprises a tissue-specific promoter, preferably a liver-specific promoter.
For example, the enhancer is a liver-specific enhancer element.
According to the invention, the transcription regulatory sequence comprises a tissue-specific promoter, particularly a liver-specific promoter.
Alanine aminotransferase ( ALT ) is considered a liver-specific enzyme, although small amounts are present in the heart.
A nucleic acid construction according to claim 7, wherein the promoter is a liver-specific promoter.
According to a further particular embodiment, the liver-specific promoter is from the transthyretin ( TTR ) gene.
The nucleic acid construct according to claim 2, wherein said promoter is a liver-specific promoter.
Ii at least one liver-specific promoter ;.
Hepatitis C virus, or HCV, infection typically persists for a decade or longer without causing liver-specific symptoms.
The term " liver-specific promoter " encompasses any promoter that confers liver-specific expression to a ( trans ) gene.
