Examples of 'locked nucleic' in a sentence
Meaning of "locked nucleic"
locked nucleic - 'Locked nucleic' usually refers to a type of nucleic acid analog that contains modifications designed to increase its stability and binding affinity. These modifications involve a 'locked' conformation of the ribose ring. Locked nucleic acids are commonly used in molecular biology and biotechnology applications
How to use "locked nucleic" in a sentence
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locked nucleic
A locked nucleic acid nucleotide is a modified ribonucleotide.
Preferably said synthesized nucleic acids are locked nucleic acids.
A locked nucleic acid nucleotide.
Such preferred derivatized sugar moieties comprise Locked Nucleic Acid.
Locked nucleic acid.
Peptide nucleic acid, locked nucleic acid or a small molecule.
In another embodiment, the oligonucleotides are composed of locked nucleic acids.
Examples of such modified nucleotides include locked nucleic acids, or nucleotides having phosphorothioate linkages.
For example, a primer having increased thermodynamic stability may contain a locked nucleic acid.
A locked nucleic acid is a modified RNA nucleotide having the following structure,.
The probe can also comprise a modification in its structure, such as a locked nucleic acid.
Typically, a locked nucleic acid is a modified and thus inaccessible RNA nucleotide.
The synthetic nucleotides may be or comprise phosphorothioate nucleotides and / or locked nucleic acid nucleotides.
Synthetic procedures for locked nucleic acids Singh et al, Chem.
In a preferred embodiment, the modified nucleotide is a Locked Nucleic Acid.
See also
An oval indicate insertion of Locked Nucleic Acids ( LNAs ) in forward and reverse primers.
In some cases the oligonucleotides may comprise locked nucleic acids ( LNAs ).
Locked nucleic acids ( INA ) in probe sequences are marked by bold italics.
Examples of such mimics equivalents are peptide nucleic acid, locked nucleic acid and / or a morpholino phosphorodiamidate.
The chemically modified oligonucleotide of claim 1, wherein said second sequence comprises 3 locked nucleic acids.
Preferably, the modified nucleotides are locked nucleic acid molecules, including a-L-LNA.
A locked nucleic acid ( LNA ), often referred to as inaccessible RNA, is a modified RNA nucleotide.
Exemplary moieties include phosphorothioates ( PTO ) or locked nucleic acid backbones.
Locked nucleic acids, or LNA 's, could also be incorporated.
The molecules of the application were also compared to Locked Nucleic Acid ( INA ) modified primers.
Locked nucleic acids, or LNA 's, Unlocked nucleic acids, or UNA 's could also be incorporated.
Fluoroquinolone resistance detection in Mycobacterium tuberculosis with locked nucleic acid probe real-time PCR.
For example, Locked Nucleic Acids ( " LNA " ) can be used to increase probe duplex stability.
Preferably, the modified nucleobases are locked nucleic acid molecules, including a-L-LNA.
Includes nucleotides containing other modifications, such as found in locked nucleic acids ( LNAs ).
Preferably, the modified nucleotides arc locked nucleic acid molecules, including a-L-LNA.
In one instance, the nucleotides are substituted with locked nucleic acids ( INA ).
Preferably, the modified nucleotides are locked nucleic acid molecules, including [ alpha ] - L-LNAs.
In one embodiment, the nucleotides are substituted with locked nucleic acids ( INA ).
Preferably, the modified nucleotides are locked nucleic acid molecules, including . alpha . - L-LNA.
A nucleotide containing a bicyclic sugar is often referred to as a locked nucleic acid ( “ LNA ” ) residue.
The term " LNA " relates to locked nucleic acids.
The oligomer of the present invention comprises at least 1 locked nucleic acid ( INA ).
In one embodiment, the stabilized RNA is a locked nucleic acid ( INA ) oligonucleotide.
In other embodiments, only sequence ( F ) of the SA DNA will comprise locked nucleic acids ( LNA ).
Examples of nucleic acid molecules include DNA, RNA, locked nucleic acid ( INA ), complementary DNA ( cDNA ).
The one or more polynucleotide comprises one or more locked nucleic acids ( INA ), or.
In other embodiments, the probe is comprised of locked nucleic acids ( INA ) Sorenson et al.
In some embodiments, a modified polynucleotide oligomer comprises a locked nucleic acid ( " LNA " ) sugar.
In one embodiment, the antisense molecule is a locked nucleic acid ( INA ) oligonucleotide.
In yet another embodiment, the oligonucleotide comprises Locked Nucleic Acids ( INA ™ ).
The oligonucleobases can also be Locked Nucleic Acids ( LNAs ).
The novel oligonucleotides are composed of at least one Locked Nucleic Acid ( INA ) alpha-L-oxy INA.
Examples thereof are peptide nucleic acids ( PNAs ), locked nucleic acids ( LNAs ), inosine etc.
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