Examples of 'lumacaftor' in a sentence
Meaning of "lumacaftor"
lumacaftor (noun) - a drug used in combination with ivacaftor to treat cystic fibrosis in some patients. Example: The doctor prescribed lumacaftor to improve the patient's condition
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- An experimental drug for the treatment of cystic fibrosis.
How to use "lumacaftor" in a sentence
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lumacaftor
It is unknown if lumacaftor or ivacaftor are found in human milk.
There was negligible urinary excretion of lumacaftor as unchanged drug.
Lumacaftor and ivacaftor.
The active substances are lumacaftor and ivacaftor.
Lumacaftor had no effects on fertility and reproductive performance indices in male and female rats.
The two drugs are called ivacaftor and lumacaftor.
Lumacaftor and ivacaftor work together to improve the function of the abnormal CFTR protein.
It is a combination drug that consists of lumacaftor and ivacaftor.
Lumacaftor and ivacaftor are inhibitors of BCRP.
Treatment combines ivacaftor and lumacaftor.
In vitro studies indicate that lumacaftor is a substrate of Breast Cancer Resistance Protein BCRP.
This is a combination product that contains two medications, ivacaftor and lumacaftor.
In vitro experiments show that lumacaftor is a substrate for Breast Cancer Resistance Protein BCRP.
Orkambi contains the active substances lumacaftor and ivacaftor.
It is unknown whether lumacaftor and / or ivacaftor and metabolites are excreted in human milk.
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Orkambi contains two active substances, lumacaftor and ivacaftor.
Lumacaftor is a strong inducer of CYP3A.
In vitro studies indicated that lumacaftor has the potential to both inhibit and induce P-gp.
Specifically, the CFTR corrector is lumacaftor.
Lumacaftor is approximately 99 % bound to plasma proteins, primarily to albumin.
Co-administration of Orkambi with medicinal products that inhibit BCRP may increase plasma lumacaftor concentration.
Lumacaftor inhibits the organic anion transporter ( OAT ) 1 and 3.
In healthy subjects, the half-life of ivacaftor when given with lumacaftor is approximately 9 hours.
Table 9, Mean ( SD ) lumacaftor and ivacaftor exposure by age group.
The combination drug is a single pill containing 200 mg of lumacaftor and 125 mg of ivacaftor.
In the U.S., the combination of lumacaftor and ivacaftor received Breakthrough Therapy Designation in late 2012.
