Examples of 'lysosomal enzyme' in a sentence
Meaning of "lysosomal enzyme"
lysosomal enzyme: Refers to a type of protein or biological catalyst present in lysosomes, which are cellular organelles responsible for breaking down waste materials. This phrase is frequently used in biology and medicine to describe enzymes that function within the lysosomal compartment
How to use "lysosomal enzyme" in a sentence
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lysosomal enzyme
Examples include lysosomal enzyme inhibitors in general.
Each metabolic process is catalyzed by a specific resident lysosomal enzyme.
This lysosomal enzyme normally degrades galactosylceramide to ceramide and galactose.
The invention permits targeting of a lysosomal enzyme to a lysosome.
Providing a lysosomal enzyme having at least one carbonyl group ; and.
Acidification of phagosomes is initiated before lysosomal enzyme activity is detected.
The lysosomal enzyme is an acid ( carboxyl ) proteinase with essential thiol groups.
Nucleic acids encoding targeted therapeutic lysosomal enzyme fusión proteins.
Ceramidease ( acid ) is a lysosomal enzyme involved in the recycling and catabolism of ceramides.
Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase.
In a preferred embodiment, the lysosomal enzyme is fused in the peptide as a fusión protein.
One or more lysine residues can also be modified on the recombinant human lysosomal enzyme.
The formulations comprise a recombinant lysosomal enzyme of the invention and a pharmaceutically acceptable carrier.
Concanavalin A is known to leach from columns and contaminate lysosomal enzyme preparations.
In one embodiment, the lysosomal enzyme and the peptide are non-covalently associated.
See also
The expression construct is specifically engineered to target the lysosomal enzyme for vacuolar localization.
I2S is a lysosomal enzyme responsible for the metabolism of mucopolysaccharides.
In another embodiment, the protein is a lysosomal enzyme.
The lysosomal enzyme is glucocerebrosidase ( GCD ) having glucocerebrosidase catalytic activity.
In an embodiment, the active principle is a lysosomal enzyme.
The lysosomal enzyme used by the method is human glucocerebrosidase ( GCD ) having glucocerebrosidase catalytic activity.
Additionally, it preserves glutathione levels and prevents lysosomal enzyme disruption.
A suitable modified recombinant human lysosomal enzyme includes acid a-glucosidase for the treatment of Pompe disease.
This cell-based method is capable of great sensitivity in detecting lysosomal enzyme activity.
The lysosomal enzyme alpha-galactosidase A is encoded by a single gene, the GNA gene.
Composition for the use according to claim 3, wherein the active principle is a lysosomal enzyme.
In some embodiments, a highly phosphorylated lysosomal enzyme is a highly phosphorylated human GAA.
In certain embodiments, the methods further comprise adding a reducing agent to the coupled lysosomal enzyme.
The mutation typically results in a deficient form of a lysosomal enzyme called palmitoyl protein thioesterase 1 PPT1.
This was confirmed directly by measurements of photochemical inactivation of the lysosomal enzyme B-AGA.
The method of claim 9, wherein the lysosomal enzyme is acid a-glucosidase.
Fabry disease-causing mutations in the GLA gene result in a deficiency of the lysosomal enzyme.
A suitable recombinant human lysosomal enzyme includes a human acid a-glucosidase ( rhGAA ).
The method of claim 3, wherein the enzyme is a lysosomal enzyme.
More preferably, the lysosomal enzyme is glucocerebrosidase ( GCD ).
The method of paragraph 3, wherein the enzyme is a lysosomal enzyme.
Also most preferably, the lysosomal enzyme is glucocerebrosidase ( GCD ).
The oligosaccharide-protein conjugate of any one of claims 2 to 5, wherein the protein is a lysosomal enzyme.
The use or compound of claims 1-3 wherein the lysosomal enzyme is prevented from being degraded.
There are 11 known forms of MPS, each involving a different lysosomal enzyme.
Tanaka T ; Chediak-Higashi syndrome, abnormal lysosomal enzyme levels in granulocytes of patients and family members.
Lysosomal enzyme over-expression in HSPC.
In one embodiment, the LSD is a defect in lysosomal enzyme protection.
The a-Gal A is a lysosomal enzyme encoded by a " housekeeping " gene.
The compound for use according to Claim 8, wherein the lysosomal enzyme is glucocerebrosidase.
The lysosomal enzyme used by the method is glucocerebrosidase ( GCD ) of SEQ ID NO, 8.
Children with Pompe disease have a defi ciency of the lysosomal enzyme acid alpha-glucosidase GAA.
The oligosaccharide-protein conjugate of E9, wherein the glycoprotein is a lysosomal enzyme.
Preferably, the enzyme is selected from the group lysosomal enzyme galactocerebrosidase and gp91 phox.
ELAPRASE is a formulation of idursulfase, a purified form of human iduronate-2-sulfatase, a lysosomal enzyme.
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Synthesis of lysosomal enzymes is controlled by nuclear genes
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Synthesis of lysosomal enzymes are controlled by nuclear genes
